Your browser doesn't support javascript.
Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors.
Pollastri, Sara; Delaunay, Clara; Thépaut, Michel; Fieschi, Franck; Bernardi, Anna.
  • Pollastri S; Università degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, Milano, Italy. anna.bernardi@unimi.it.
  • Delaunay C; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France. franck.fieschi@ibs.fr.
  • Thépaut M; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France. franck.fieschi@ibs.fr.
  • Fieschi F; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale, 38000 Grenoble, France. franck.fieschi@ibs.fr.
  • Bernardi A; Università degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, Milano, Italy. anna.bernardi@unimi.it.
Chem Commun (Camb) ; 58(33): 5136-5139, 2022 Apr 21.
Article in English | MEDLINE | ID: covidwho-1774005
ABSTRACT
The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. We tested C2 triazole-modified mono- and pseudo-di-mannosides as inhibitors of DC/L-SIGN binding to a model mannosylated protein (Man-BSA) and to SARS-CoV2 spike, finding that they inhibit the interaction of both lectins with the spike glycoprotein in a Surface Plasmon Resonance (SPR) assay and are more potent than mannose by up to 36-fold (DC-SIGN) and 10-fold (L-SIGN). The molecules described here are the first known glycomimetic ligands of L-SIGN.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: D2cc00121g

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / COVID-19 Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: D2cc00121g