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Large thrombus in transit in a COVID-19 patient.
Bleiziffer, Sabine; Zabel, Reinhard; Gummert, Jan F; Deutsch, Marcus-André.
  • Bleiziffer S; Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, University Hospital Ruhr-University Bochum, Bad Oeynhausen, Germany.
  • Zabel R; Institute of Radiology, Nuclear Medicine and Molecular Imaging, Heart and Diabetes Center North Rhine-Westphalia Bochum, University Hospital of the Ruhr-University, Bad Oeynhausen, Germany.
  • Gummert JF; Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, University Hospital Ruhr-University Bochum, Bad Oeynhausen, Germany.
  • Deutsch MA; Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine-Westphalia, University Hospital Ruhr-University Bochum, Bad Oeynhausen, Germany.
Interact Cardiovasc Thorac Surg ; 35(2)2022 07 09.
Article in English | MEDLINE | ID: covidwho-1774387
ABSTRACT
The course of COVID-19 patients may be complicated by thromboembolic events. We report on a 48-year-old female COVID-19 patient who underwent surgical removal of a large intracardiac thrombus. As per our centre protocol, critically ill COVID-19 patients are anticoagulated by the direct thrombin inhibitor Argatroban with close monitoring of anti-IIa activity. An intra-atrial thrombus formation fixed in a patent foramen ovale but also large mobile portions in both atria was diagnosed 4 days after weaning and removal of the jugular and femoral extracorporeal membrane oxygenation cannulas. The thrombus was removed surgically via median sternotomy and on cardiopulmonary bypass. The thrombus had a bizarre appearance with several finger-like appendices, and histological analysis revealed a mixed picture of acute and chronic thrombus portions. This case highlights the risk of life-threatening thrombus formation in COVID-19 patients despite therapeutic thrombin inhibition.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / Thrombosis / Foramen Ovale, Patent / COVID-19 / Heart Diseases Type of study: Case report / Prognostic study Topics: Long Covid Limits: Female / Humans / Middle aged Language: English Journal subject: Vascular Diseases / Cardiology Year: 2022 Document Type: Article Affiliation country: Icvts

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / Thrombosis / Foramen Ovale, Patent / COVID-19 / Heart Diseases Type of study: Case report / Prognostic study Topics: Long Covid Limits: Female / Humans / Middle aged Language: English Journal subject: Vascular Diseases / Cardiology Year: 2022 Document Type: Article Affiliation country: Icvts