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Histopathological analysis of skin reactions after coronavirus disease 2019 vaccination: Increment in number of infiltrated plasmacytoid dendritic cell.
Watanabe, Hanako; Ashida, Miwa; Satomi, Naoyoshi; Koike, Yuta; Kuwatsuka, Sayaka; Murota, Hiroyuki.
  • Watanabe H; Department of Dermatology, Nagasaki University Hospital, Nagasaki, Japan.
  • Ashida M; Department of Dermatology, Nagasaki University Hospital, Nagasaki, Japan.
  • Satomi N; Department of Dermatology, Nagasaki University Hospital, Nagasaki, Japan.
  • Koike Y; Department of Dermatology, Nagasaki University Hospital, Nagasaki, Japan.
  • Kuwatsuka S; Department of Dermatology, Nagasaki University Hospital, Nagasaki, Japan.
  • Murota H; Department of Dermatology, Nagasaki University Hospital, Nagasaki, Japan.
J Dermatol ; 49(7): 732-735, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1774698
ABSTRACT
Skin disorders are frequent adverse events after coronavirus disease 2019 (COVID-19) vaccination. However, the pathogenesis of these disorders is not fully understood. Here, we report a case series of cutaneous adverse events following COVID-19 vaccination, and the results of our investigation reveal the underlying mechanism. Case 1 a 47-year-old female developed a wheal, confined to the COVID-19 vaccination site, 2 days after her first injection. She was treated with topical steroids and oral antihistamines. Case 2 a 51-year-old female showed generalized petechial erythema accompanied by fever, genital bleeding, thrombocytopenia, liver dysfunction, and disseminated intravascular coagulation, 2 days after her second injection. She was diagnosed with vaccine-induced macrophage activation syndrome and treated with anti-inflammatory therapy. Immunohistological analysis of the skin eruption, in both these cases, showed infiltration of CD123+ BDCA2+ plasmacytoid dendritic cells (p-DC). Despite the distinctive clinical features in these two cases, this finding suggests that p-DC might be involved in different cutaneous adverse events after COVID-19 vaccination.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dendritic Cells / Erythema / COVID-19 Vaccines / COVID-19 Type of study: Case report / Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Middle aged Language: English Journal: J Dermatol Year: 2022 Document Type: Article Affiliation country: 1346-8138.16374

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dendritic Cells / Erythema / COVID-19 Vaccines / COVID-19 Type of study: Case report / Observational study / Prognostic study Topics: Vaccines Limits: Female / Humans / Middle aged Language: English Journal: J Dermatol Year: 2022 Document Type: Article Affiliation country: 1346-8138.16374