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Histopathology of persistent long COVID toe: A case report.
Nirenberg, Michael S; Requena, Luis; Santonja, Carlos; Smith, Gregory T; McClain, Steve A.
  • Nirenberg MS; Friendly Foot Care, P.C., Crown Point, Indiana, USA.
  • Requena L; Department of Dermatology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
  • Santonja C; Department of Pathology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
  • Smith GT; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, USA.
  • McClain SA; Department of Dermatology, Stony Brook University, Stony Brook, New York, USA.
J Cutan Pathol ; 49(9): 791-794, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1774773
ABSTRACT
During the 2020 coronavirus (SARS-CoV-2) pandemic, several cutaneous lesions were identified, including pseudo-chilblain, vesicular, urticarial, maculopapular, and livedo/necrosis. A 59-year-old obese man with probable COVID-19 developed painful cyanosis with histopathologic capillary thrombosis of toes, and the cyanosis persisted for nearly 22 months. Shortly after initial exposure to family members with documented SARS-CoV-2, he developed upper respiratory symptoms, yet his anti-SARS-CoV-2 antibody and nasal swab RT-PCR tests were repeatedly negative. Two family members were hospitalized and one of them succumbed with documented SARS-CoV-2 pneumonia within 10 days of exposure. Biopsy specimen of the distal toe 16 weeks after initial exposure showed papillary dermal capillary thrombosis with endothelial swelling, telangiectasia, and peri-eccrine lymphocytic infiltrates resembling pernio. Overall, this is the first case of biopsy specimen of "long COVID toe" following presumed SARS-CoV-2 exposure, with a demonstration of thrombotic vasculopathy, toe cyanosis, and pernio-like pathology.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Toes / Cyanosis / COVID-19 Type of study: Case report Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: J Cutan Pathol Year: 2022 Document Type: Article Affiliation country: Cup.14240

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombosis / Toes / Cyanosis / COVID-19 Type of study: Case report Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: J Cutan Pathol Year: 2022 Document Type: Article Affiliation country: Cup.14240