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Protocol for SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home): feasibility of a home-based double-blind randomised controlled trial to improve gait and cognition in individuals at risk for dementia.
McGibbon, Chris; Jarrett, Pam; Handrigan, Grant; Bouchard, Danielle; Tranchant, Carole C; Sexton, Andrew M; Yetman, Linda; Robinson, Bryn; Crapoulet, Stephanie; Chamard-Witkowski, Ludivine; Liu-Ambrose, Teresa; Middleton, Laura Elizabeth; Almeida, Quincy J; Bherer, Louis; Lim, Andrew; Speechley, Mark; Kamkar, Nellie; Montero Odasso, Manuel.
  • McGibbon C; Faculty of Kinesiology, University of New Brunswick Fredericton, Fredericton, New Brunswick, Canada cmcgibb@unb.ca.
  • Jarrett P; Institute of Biomedical Engineering, University of New Brunswick, Fredericton, New Brunswick, Canada.
  • Handrigan G; Department of Geriatric Medicine, Horizon Health Network, Saint John, New Brunswick, Canada.
  • Bouchard D; Faculty of Medicine, Deptartment of Internal Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
  • Tranchant CC; Faculty of Health Sciences and Community Services, School of Kinesiology and Recreation, Universite de Moncton, Moncton, New Brunswick, Canada.
  • Sexton AM; Faculty of Kinesiology, University of New Brunswick Fredericton, Fredericton, New Brunswick, Canada.
  • Yetman L; Faculty of Health Sciences and Community Services, School of Food Science, Nutrition and Family Studies, Universite de Moncton, Moncton, New Brunswick, Canada.
  • Robinson B; Institute of Biomedical Engineering, University of New Brunswick, Fredericton, New Brunswick, Canada.
  • Crapoulet S; Research Services, Horizon Health Network, Saint John, New Brunswick, Canada.
  • Chamard-Witkowski L; Research Services, Horizon Health Network, Saint John, New Brunswick, Canada.
  • Liu-Ambrose T; Research Services, Vitalite Health Network, Moncton, New Brunswick, Canada.
  • Middleton LE; Department of Neuroscience, Dr Georges-L-Dumont University Hospital Centre, Moncton, New Brunswick, Canada.
  • Almeida QJ; Department of Physical Therapy, The University of British Columbia, Vancouver, British Columbia, Canada.
  • Bherer L; Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.
  • Lim A; Faculty of Science, Department of Kinesiology and Physical Education, Wilfrid Laurier University, Waterloo, Ontario, Canada.
  • Speechley M; Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
  • Kamkar N; Neurology Division, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
  • Montero Odasso M; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada.
BMJ Open ; 12(3): e059988, 2022 03 31.
Article in English | MEDLINE | ID: covidwho-1774970
ABSTRACT

INTRODUCTION:

Physical exercise and cognitive training have the potential to enhance cognitive function and mobility in older adults at risk of Alzheimer's disease and related dementia (ADRD), but little is known about the feasibility of delivering multidomain interventions in home settings of older adults at risk of ADRD. This study aims to assess the feasibility of home-based delivery of exercise and cognitive interventions, and to evaluate the relationship between participants' intervention preferences and their subsequent adherence. Secondary objectives include the effect of the interventions on ADRD risk factors, including frailty, mobility, sleep, diet and psychological health. METHODS AND

ANALYSIS:

The SYNchronising Exercises, Remedies in GaIt and Cognition at Home (SYNERGIC@Home) feasibility trial is a randomised control trial that follows a 2×2 factorial design, with a 16-week home-based intervention programme (3 sessions per week) of physical exercises and cognitive training. Participants will be randomised in blocks of four to one of the following four arms (1) combined exercise (aerobic and resistance)+cognitive training (NEUROPEAK); (2) combined exercise+control cognitive training (web searching); (3) control exercise (balance and toning)+cognitive training; and (4) control exercise+control cognitive training. SYNERGIC@Home will be implemented through video conferencing. Baseline and post-intervention assessments at 4-month and 10-month follow-up will include measures of cognition, frailty, mobility, sleep, diet and psychological health. Primary feasibility outcome is adherence to the interventions. Primary analytic outcome is the relationship between pre-allocation preference for a given intervention and subsequent adherence to the allocated intervention. A series of secondary analytic outcomes examining the potential effect of the individual and combined interventions on cognitive, mobility and general well-being will be measured at baseline and follow-up. ETHICS AND DISSEMINATION Ethics approval was granted by the relevant research ethics boards. Findings of the study will be presented to stakeholders and published in peer-reviewed journals and at provincial, national and international conferences. TRIAL REGISTRATION NUMBER NCT04997681, Pre-results.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cognition / Alzheimer Disease Type of study: Cohort study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Aged / Humans Language: English Journal: BMJ Open Year: 2022 Document Type: Article Affiliation country: Bmjopen-2021-059988

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cognition / Alzheimer Disease Type of study: Cohort study / Experimental Studies / Prognostic study / Randomized controlled trials Limits: Aged / Humans Language: English Journal: BMJ Open Year: 2022 Document Type: Article Affiliation country: Bmjopen-2021-059988