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Acute Myocardial Injury Assessed by High-Sensitive Cardiac Troponin Predicting Severe Outcomes and Death in Hospitalized Patients with COVID-19 Infection.
Laouan Brem, Falmata; Chaymae, Miri; Rasras, Hammam; Merbouh, Manal; Bouazzaoui, Mohammed-Amine; Bkiyar, Houssam; Abda, Naima; Zakaria, Bazid; Ismaili, Nabila; Housni, Brahim; El Ouafi, Noha.
  • Laouan Brem F; Department of Cardiology, 470522Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco.
  • Chaymae M; Department of Cardiology, 470522Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco.
  • Rasras H; Department of Cardiology, 470522Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco.
  • Merbouh M; Department of Anesthesia and Intensive Care, 470522Mohamed VI University Hospital Center, Mohamed I University, Oujda, Morocco.
  • Bouazzaoui MA; Epidemiological Laboratory of Clinical Research and Public Health, Faculty of Medicine and Pharmacy of Oujda, 479153Mohammed First University, Oujda, Morocco.
  • Bkiyar H; Department of Anesthesia and Intensive Care, 470522Mohamed VI University Hospital Center, Mohamed I University, Oujda, Morocco.
  • Abda N; Epidemiological Laboratory of Clinical Research and Public Health, Faculty of Medicine and Pharmacy of Oujda, 479153Mohammed First University, Oujda, Morocco.
  • Zakaria B; Department of Cardiology, 470522Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco.
  • Ismaili N; Department of Cardiology, 470522Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco.
  • Housni B; Epidemiological Laboratory of Clinical Research and Public Health, Faculty of Medicine and Pharmacy of Oujda, 479153Mohammed First University, Oujda, Morocco.
  • El Ouafi N; Department of Anesthesia and Intensive Care, 470522Mohamed VI University Hospital Center, Mohamed I University, Oujda, Morocco.
Clin Appl Thromb Hemost ; 28: 10760296221090227, 2022.
Article in English | MEDLINE | ID: covidwho-1775236
ABSTRACT

BACKGROUND:

Cardiac injury has been linked to a poor prognosis during COVID-19 disease. Nevertheless, the risk factors associated are yet to be thoroughly investigated.

OBJECTIVES:

We sought to compare demographical characteristics and in-hospital outcomes in patients infected by the SARS-CoV-2 with and without cardiac injury, to further investigate the prevalence of acute cardiac injury as well as its impact on their outcomes in COVID-19-patients.

METHODS:

We included in a retrospective analysis, all COVID-19 patients admitted between October first and December first, 2020, at the University Hospital Center of Oujda (Morocco) who underwent a troponin assay which was systematically measured on admission. The study population was divided into two groups cardiac-injured patients and those without cardiac injury. Clinical, biological data and in-hospital outcomes were compared between the two groups.

RESULTS:

298 confirmed COVID-19 cases were included. Our study found that compared to non-cardiac-injured, cardiac-injured patients are older, with higher possibilities of existing comorbidities including hypertension (68 [42.2%] vs 40 [29.2%], P = 0.02), diabetes (81 [50.3%] vs 53 [38.7%] P = 0.044), the need for mechanical ventilation, ICU admission and mortality. A Cox proportional hazards regression analysis shows a significantly increased risk of death among cardiac-injured COVID-19-patients as compared to non-cardiac injured. (HR, 1.620 [CI 95% 2.562-1.024]).

CONCLUSION:

Our retrospective cohort found that old age, comorbidities, a previous history of CAD, were significantly associated with acute cardiac injury. COVID-19 patients with acute cardiac injury are at a higher risk of ICU admission, and death.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Troponin / COVID-19 / Heart Diseases Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Clin Appl Thromb Hemost Journal subject: Vascular Diseases Year: 2022 Document Type: Article Affiliation country: 10760296221090227

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Troponin / COVID-19 / Heart Diseases Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Clin Appl Thromb Hemost Journal subject: Vascular Diseases Year: 2022 Document Type: Article Affiliation country: 10760296221090227