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Soluble Angiotensin-Converting Enzyme 2 as a Prognostic Biomarker for Disease Progression in Patients Infected with SARS-CoV-2.
Díaz-Troyano, Noelia; Gabriel-Medina, Pablo; Weber, Stephen; Klammer, Martin; Barquín-DelPino, Raquel; Castillo-Ribelles, Laura; Esteban, Angels; Hernández-González, Manuel; Ferrer-Costa, Roser; Pumarola, Tomas; Rodríguez-Frías, Francisco.
  • Díaz-Troyano N; Biochemistry Department (Clinical Laboratories), Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
  • Gabriel-Medina P; Vall d'Hebron Research Institute, 08035 Barcelona, Spain.
  • Weber S; Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
  • Klammer M; Biochemistry Department (Clinical Laboratories), Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
  • Barquín-DelPino R; Vall d'Hebron Research Institute, 08035 Barcelona, Spain.
  • Castillo-Ribelles L; Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
  • Esteban A; Roche Diagnostics GmbH, 82377 Penzberg, Germany.
  • Hernández-González M; Roche Diagnostics GmbH, 82377 Penzberg, Germany.
  • Ferrer-Costa R; Biochemistry Department (Clinical Laboratories), Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
  • Pumarola T; Vall d'Hebron Research Institute, 08035 Barcelona, Spain.
  • Rodríguez-Frías F; Biochemistry Department (Clinical Laboratories), Vall d'Hebron University Hospital, 08035 Barcelona, Spain.
Diagnostics (Basel) ; 12(4)2022 Apr 01.
Article in English | MEDLINE | ID: covidwho-1776155
ABSTRACT
Predicting disease severity in patients infected with SARS-CoV-2 is difficult. Soluble angiotensin-converting enzyme 2 (sACE2) arises from the shedding of membrane ACE2 (mACE2), which is a receptor for SARS-CoV-2 spike protein. We evaluated the predictive value of sACE2 compared with known biomarkers of inflammation and tissue damage (CRP, GDF-15, IL-6, and sFlt-1) in 850 patients with and without SARS-CoV-2 with different clinical outcomes. For univariate analyses, median differences between biomarker levels were calculated for the following patient groups (classified by clinical outcome) RT-PCR-confirmed SARS-CoV-2 positive (Groups 1-4); RT-PCR-confirmed SARS-CoV-2 negative following previous SARS-CoV-2 infection (Groups 5 and 6); and 'SARS-CoV-2 unexposed' patients (Group 7). Median levels of CRP, GDF-15, IL-6, and sFlt-1 were significantly higher in hospitalized patients with SARS-CoV-2 compared with discharged patients (all p < 0.001), whereas levels of sACE2 were significantly lower (p < 0.001). ROC curve analysis of sACE2 provided cut-offs for predicting hospital admission (≤0.05 ng/mL (positive predictive value 89.1%) and ≥0.42 ng/mL (negative predictive value 84.0%)). These findings support further investigation of sACE2, as a single biomarker or as part of a panel, to predict hospitalization risk and disease severity in patients with SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Diagnostics12040886

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Year: 2022 Document Type: Article Affiliation country: Diagnostics12040886