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Small Fibre Peripheral Alterations Following COVID-19 Detected by Corneal Confocal Microscopy.
Midena, Edoardo; Cosmo, Eleonora; Cattelan, Anna Maria; Briani, Chiara; Leoni, Davide; Capizzi, Alfio; Tabacchi, Vanessa; Parrozzani, Raffaele; Midena, Giulia; Frizziero, Luisa.
  • Midena E; Ophthalmology Unit, Department of Neuroscience, University of Padova, 35128 Padova, Italy.
  • Cosmo E; IRCCS-Fondazione Bietti, 00198 Rome, Italy.
  • Cattelan AM; IRCCS-Fondazione Bietti, 00198 Rome, Italy.
  • Briani C; Unit of Infectious Disease, Department of Internal Medicine, University of Padova, 35128 Padova, Italy.
  • Leoni D; Neurology Unit, Department of Neuroscience, University of Padova, 35128 Padova, Italy.
  • Capizzi A; Unit of Infectious Disease, Department of Internal Medicine, University of Padova, 35128 Padova, Italy.
  • Tabacchi V; Department of Directional Hospital Management, University of Padova, 35128 Padova, Italy.
  • Parrozzani R; Ophthalmology Unit, Department of Neuroscience, University of Padova, 35128 Padova, Italy.
  • Midena G; Ophthalmology Unit, Department of Neuroscience, University of Padova, 35128 Padova, Italy.
  • Frizziero L; IRCCS-Fondazione Bietti, 00198 Rome, Italy.
J Pers Med ; 12(4)2022 Apr 01.
Article in English | MEDLINE | ID: covidwho-1776272
ABSTRACT
A large spectrum of neurological manifestations has been associated with coronavirus disease 2019 (COVID-19), and recently, the involvement of small fibers has been suggested. This study aims to investigate the involvement of small peripheral nervous fibers in recovered COVID-19 patients using in-vivo corneal confocal microscopy (CCM). Patients recovered from COVID-19 and a control group of healthy subjects underwent in-vivo CCM. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), corneal nerve fiber total branch density (CTBD), corneal nerve fiber area (CNFA), corneal nerve fiber width (CNFW), fiber tortuosity (FT), number of beadings (NBe), and dendritic cells (DC) density were quantified. We enrolled 302 eyes of 151 patients. CNBD and FT were significantly higher (p = 0.0131, p < 0.0001), whereas CNFW and NBe were significantly lower (p = 0.0056, p = 0.0045) in the COVID-19 group compared to controls. Only CNBD and FT resulted significantly correlated to antiviral drugs (increased) and corticosteroids (decreased). No significant relationship with disease severity parameters was found. COVID-19 may induce peripheral neuropathy in small fibers even months after recovery, regardless of systemic conditions and therapy, and CCM may be a useful tool to identify and monitor these morphological changes.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Year: 2022 Document Type: Article Affiliation country: Jpm12040563

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Year: 2022 Document Type: Article Affiliation country: Jpm12040563