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SARS-CoV-2 vaccine, a new autoimmune hepatitis trigger?
López Romero-Salazar, Francisco; Veras Lista, Mariña; Gómez-Domínguez, Elena; Ibarrola-Andrés, Carolina; Muñoz Gómez, Raquel; Fernández Vázquez, Inmaculada.
  • López Romero-Salazar F; Medicina del Aparato Digestivo, Hospital Universitario 12 de Octubre, España.
  • Veras Lista M; Anatomía Patológica, Hospital Universitario 12 de Octubre.
  • Gómez-Domínguez E; Medicina del Aparato Digestivo, Hospital Universitario 12 de Octubre.
  • Ibarrola-Andrés C; Anatomía Patológica, Hospital Universitario 12 de Octubre, España.
  • Muñoz Gómez R; Medicina del Aparato Digestivo, Hospital Universitario 12 de Octubre.
  • Fernández Vázquez I; Medicina del Aparato Digestivo, Hospital Universitario 12 de Octubre.
Rev Esp Enferm Dig ; 114(9): 567-568, 2022 09.
Article in English | MEDLINE | ID: covidwho-1776738
ABSTRACT
SARS-CoV2 infection and vaccination against this virus have been related to the development of autoimmune diseases. We report a case of autoimmune hepatitis (AIH) after SARS-COV2 vaccine. Male, 76 years old, with a history of hepatic cirrhosis secondary to primary biliary cholangitis (PBC), compensated, treated with ursodeoxycholic acid and obeticholic acid. The patient received the third dose of the SARS-CoV2 vaccine (BioNTech/Pfizer) in December 2021. In subsequent analytical control, the patient presented altered liver test, with elevation of ALT and AST. Ultrasound was performed, without alterations, and viral causes were ruled out. IgG elevation and positive antinuclear antibodies were observed. A liver biopsy was performed, with findings of intense interface and lobular hepatitis and areas of centrilobular necrosis. The inflammation was predominantly lymphoplasmacytic. The patient was diagnosed with AIH and initiated therapy with steroids and azathioprine, currently with an adequate response. AIH is an immune-mediated disease of uncertain etiology. Cases of AIH with SARS-CoV2 vaccination as a possible trigger have recently been published, with characteristics similar to ours. Some of them had a history of autoimmune pathology, such as this case (PBC). Therefore, it is suggested that vaccination can induce the development of autoimmune pathology in patients at risk. Our reported case reinforces the hypothesis of an association between AIH and the SARS-CoV2 vaccine.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hepatitis, Autoimmune / COVID-19 Vaccines / COVID-19 / Liver Cirrhosis, Biliary Type of study: Case report / Etiology study / Observational study / Prognostic study Topics: Vaccines Limits: Aged / Humans / Male Language: English Journal: Rev Esp Enferm Dig Journal subject: Gastroenterology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hepatitis, Autoimmune / COVID-19 Vaccines / COVID-19 / Liver Cirrhosis, Biliary Type of study: Case report / Etiology study / Observational study / Prognostic study Topics: Vaccines Limits: Aged / Humans / Male Language: English Journal: Rev Esp Enferm Dig Journal subject: Gastroenterology Year: 2022 Document Type: Article