SARS-CoV-2 vaccine, a new autoimmune hepatitis trigger?
Rev Esp Enferm Dig
; 114(9): 567-568, 2022 09.
Article
in English
| MEDLINE | ID: covidwho-1776738
ABSTRACT
SARS-CoV2 infection and vaccination against this virus have been related to the development of autoimmune diseases. We report a case of autoimmune hepatitis (AIH) after SARS-COV2 vaccine. Male, 76 years old, with a history of hepatic cirrhosis secondary to primary biliary cholangitis (PBC), compensated, treated with ursodeoxycholic acid and obeticholic acid. The patient received the third dose of the SARS-CoV2 vaccine (BioNTech/Pfizer) in December 2021. In subsequent analytical control, the patient presented altered liver test, with elevation of ALT and AST. Ultrasound was performed, without alterations, and viral causes were ruled out. IgG elevation and positive antinuclear antibodies were observed. A liver biopsy was performed, with findings of intense interface and lobular hepatitis and areas of centrilobular necrosis. The inflammation was predominantly lymphoplasmacytic. The patient was diagnosed with AIH and initiated therapy with steroids and azathioprine, currently with an adequate response. AIH is an immune-mediated disease of uncertain etiology. Cases of AIH with SARS-CoV2 vaccination as a possible trigger have recently been published, with characteristics similar to ours. Some of them had a history of autoimmune pathology, such as this case (PBC). Therefore, it is suggested that vaccination can induce the development of autoimmune pathology in patients at risk. Our reported case reinforces the hypothesis of an association between AIH and the SARS-CoV2 vaccine.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Hepatitis, Autoimmune
/
COVID-19 Vaccines
/
COVID-19
/
Liver Cirrhosis, Biliary
Type of study:
Case report
/
Etiology study
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Rev Esp Enferm Dig
Journal subject:
Gastroenterology
Year:
2022
Document Type:
Article
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