Your browser doesn't support javascript.
Potential mechanisms underlying lithium treatment for Alzheimer's disease and COVID-19.
Wei, H-F; Anchipolovsky, S; Vera, R; Liang, G; Chuang, D-M.
  • Wei HF; Department of Anaesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, USA. Huafeng.wei@pennmedicine.upenn.edu.
Eur Rev Med Pharmacol Sci ; 26(6): 2201-2214, 2022 03.
Article in English | MEDLINE | ID: covidwho-1776800
ABSTRACT
Disruption of intracellular Ca2+ homeostasis plays an important role as an upstream pathology in Alzheimer's disease (AD), and correction of Ca2+ dysregulation has been increasingly proposed as a target of future effective disease-modified drugs for treating AD. Calcium dysregulation is also an upstream pathology for the COVID-19 virus SARS-CoV-2 infection and replication, leading to host cell damage. Clinically available drugs that can inhibit the disturbed intracellular Ca2+ homeostasis have been repurposed to treat COVID-19 patients. This narrative review aims at exploring the underlying mechanism by which lithium, a first line drug for the treatment of bipolar disorder, inhibits Ca2+ dysregulation and associated downstream pathology in both AD and COVID-19. It is suggested that lithium can be repurposed to treat AD patients, especially those afflicted with COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Alzheimer Disease / COVID-19 Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2022 Document Type: Article Affiliation country: Eurrev_202203_28369

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Alzheimer Disease / COVID-19 Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2022 Document Type: Article Affiliation country: Eurrev_202203_28369