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Short- and Long-Term Recovery after Moderate/Severe AKI in Patients with and without COVID-19.
Sun, Siao; Annadi, Raji R; Chaudhri, Imran; Munir, Kiran; Hajagos, Janos; Saltz, Joel; Hoai, Minh; Mallipattu, Sandeep K; Moffitt, Richard; Koraishy, Farrukh M.
  • Sun S; Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York.
  • Annadi RR; Department of Computer Science, Stony Brook University, Stony Brook, New York.
  • Chaudhri I; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Munir K; Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Hajagos J; Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York.
  • Saltz J; Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York.
  • Hoai M; Department of Computer Science, Stony Brook University, Stony Brook, New York.
  • Mallipattu SK; Division of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York.
  • Moffitt R; Department of Biomedical Informatics, Stony Brook University, Stony Brook, New York.
  • Koraishy FM; Division of Nephrology and Hypertension, Department of Medicine, Stony Brook University, Stony Brook, New York.
Kidney360 ; 3(2): 242-257, 2022 02 24.
Article in English | MEDLINE | ID: covidwho-1776868
ABSTRACT

Background:

Severe AKI is strongly associated with poor outcomes in coronavirus disease 2019 (COVID-19), but data on renal recovery are lacking.

Methods:

We retrospectively analyzed these associations in 3299 hospitalized patients (1338 with COVID-19 and 1961 with acute respiratory illness but who tested negative for COVID-19). Uni- and multivariable analyses were used to study mortality and recovery after Kidney Disease Improving Global Outcomes Stages 2 and 3 AKI (AKI-2/3), and Machine Learning was used to predict AKI and recovery using admission data. Long-term renal function and other outcomes were studied in a subgroup of AKI-2/3 survivors.

Results:

Among the 172 COVID-19-negative patients with AKI-2/3, 74% had partial and 44% complete renal recovery, whereas 12% died. Among 255 COVID-19 positive patients with AKI-2/3, lower recovery and higher mortality were noted (51% partial renal recovery, 25% complete renal recovery, 24% died). On multivariable analysis, intensive care unit admission and acute respiratory distress syndrome were associated with nonrecovery, and recovery was significantly associated with survival in COVID-19-positive patients. With Machine Learning, we were able to predict recovery from COVID-19-associated AKI-2/3 with an average precision of 0.62, and the strongest predictors of recovery were initial arterial partial pressure of oxygen and carbon dioxide, serum creatinine, potassium, lymphocyte count, and creatine phosphokinase. At 12-month follow-up, among 52 survivors with AKI-2/3, 26% COVID-19-positive and 24% COVID-19-negative patients had incident or progressive CKD.

Conclusions:

Recovery from COVID-19-associated moderate/severe AKI can be predicted using admission data and is associated with severity of respiratory disease and in-hospital death. The risk of CKD might be similar between COVID-19-positive and -negative patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Kidney360 Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Kidney360 Year: 2022 Document Type: Article