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Factors associated with the intention to participate in COVID-19 vaccine clinical trials: A cross-sectional study in Peru.
De-Los-Rios-Pinto, Abraham; Fernandez-Guzman, Daniel; Soriano-Moreno, David R; Sangster-Carrasco, Lucero; Morocho-Alburqueque, Noelia; Pinedo-Soria, Antony; Murrieta-Ruiz, Valentina; Diaz-Corrales, Angelica; Alave, Jorge; Nieto-Gutierrez, Wendy; Gonzales-Zamora, Jose.
  • De-Los-Rios-Pinto A; Escuela Profesional de Medicina Humana, Universidad Nacional San Antonio Abad del Cusco, Cusco, Peru.
  • Fernandez-Guzman D; Escuela Profesional de Medicina Humana, Universidad Nacional San Antonio Abad del Cusco, Cusco, Peru; Grupo Peruano de Investigación Epidemiológica, Unidad para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Perú.
  • Soriano-Moreno DR; Unidad de Investigación Clínica y Epidemiológica, Escuela de Medicina, Universidad Peruana Unión, Lima, Peru.
  • Sangster-Carrasco L; Universidad Peruana de Ciencias Aplicadas, Facultad de Medicina, Lima, Peru.
  • Morocho-Alburqueque N; Sociedad Científica de Estudiantes de Medicina de la Universidad Nacional de Piura, Piura, Perú.
  • Pinedo-Soria A; Facultad de Medicina Humana, Universidad Nacional de San Martín, Tarapoto, Peru. Electronic address: apinedos@alumno.unsm.edu.pe.
  • Murrieta-Ruiz V; Universidad Nacional de la Amazonía Peruana, Facultad de Medicina Humana Rafael Donayre Rojas, Iquitos, Loreto, Perú.
  • Diaz-Corrales A; Universidad de San Martín de Porres, Facultad de Medicina Humana, Chiclayo, Lambayeque, Peru.
  • Alave J; Universidad Peruana Union, Escuela de Medicina Humana, Lima, Peru; Deparment of Medicine, Clinica Good Hope, Lima, Peru. Electronic address: jorgealave@upeu.edu.pe.
  • Nieto-Gutierrez W; Unidad de Investigación para la Generación de Síntesis de Evidencia en Salud, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, Peru. Electronic address: wendy_nieto22@hotmail.com.
  • Gonzales-Zamora J; Division of Infectious Diseases, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL, USA; Peruvian American Medical Society, USA. Electronic address: jxg1416@med.miami.edu.
Vaccine ; 40(26): 3566-3572, 2022 Jun 09.
Article in English | MEDLINE | ID: covidwho-1778489
ABSTRACT

OBJECTIVE:

To evaluate the factors associated with the intention to participate in COVID-19 vaccine clinical trials in the Peruvian population.

METHODS:

Cross-sectional study and secondary analysis of a database that involved Peruvian population during September 2020. The Poisson regression model was used to estimate the associated factors.

RESULTS:

Data from 3231 individuals were analyzed, 44.1% of whom intended to participate in COVID-19 vaccine clinical trials. Factors associated with the outcome were being male (RPa 1.25; 95% CI 1.15-1.35), being from the highlands region (RPa 1.18; 95% CI 1.09-1.28) or jungle (RPa 1.30; 95% CI 1.15-1.47), having a relative that is a healthcare professional (PRa 1.16; 95% CI 1.06-1.28), using a medical source of information (PRa 1.28; 95% CI 1.17-1.41), and trusting in the possible effectiveness of vaccines (PRa 1.40; 95% CI 1.29-1.51). The main reason for not participating in the trial was the possibility of developing side effects (69.80%).

CONCLUSION:

There is an urgent need to generate a perception of safety in COVID-19 vaccine clinical trials, to increase the population's intention to participate in these studies, and to provide evidence-based information about the vaccine.
Subject(s)
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Patient Participation / Clinical Trials as Topic / Intention / COVID-19 Vaccines Type of study: Prevalence study / Prognostic study / Qualitative research / Randomized controlled trials / Risk factors Topics: Vaccines Limits: Female / Humans / Male Country/Region as subject: South America / Peru Language: English Journal: Vaccine Year: 2022 Document Type: Article Affiliation country: J.vaccine.2022.04.003

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Patient Participation / Clinical Trials as Topic / Intention / COVID-19 Vaccines Type of study: Prevalence study / Prognostic study / Qualitative research / Randomized controlled trials / Risk factors Topics: Vaccines Limits: Female / Humans / Male Country/Region as subject: South America / Peru Language: English Journal: Vaccine Year: 2022 Document Type: Article Affiliation country: J.vaccine.2022.04.003