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Monitoring of SARS-CoV-2 antibodies using dried blood spot for at-home collection.
Miesse, Peyton K; Collier, Bradley B; Grant, Russell P.
  • Miesse PK; Center for Esoteric Testing, Laboratory Corporation of America Holdings, Burlington, NC, USA.
  • Collier BB; Center for Esoteric Testing, Laboratory Corporation of America Holdings, Burlington, NC, USA. collib7@labcorp.com.
  • Grant RP; Center for Esoteric Testing, Laboratory Corporation of America Holdings, Burlington, NC, USA.
Sci Rep ; 12(1): 5812, 2022 04 06.
Article in English | MEDLINE | ID: covidwho-1778631
ABSTRACT
The utilization of vaccines to fight the spread of SARS-CoV-2 has led to a growing need for expansive serological testing. To address this, an EUA approved immunoassay for detection of antibodies to SARS-CoV-2 in venous serum samples was investigated for use with dried blood spot (DBS) samples. Results from self-collected DBS samples demonstrated a 98.1% categorical agreement to venous serum with a correlation (R) of 0.9600 while professionally collected DBS samples demonstrated a categorical agreement of 100.0% with a correlation of 0.9888 to venous serum. Additional studies were performed to stress different aspects of at-home DBS collection, including shipping stability, effects of interferences, and other sample-specific robustness studies. These studies demonstrated a categorical agreement of at least 95.0% and a mean bias less than ± 20.0%. Furthermore, the ability to track antibody levels following vaccination with the BioNTech/Pfizer vaccine was demonstrated with serial self-collected DBS samples from pre-dose (Day 0) out to 19 weeks.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-09699-4

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-09699-4