Filamentous bacteriophages, natural nanoparticles, for viral vaccine strategies.
Nanoscale
; 14(16): 5942-5959, 2022 Apr 21.
Article
in English
| MEDLINE | ID: covidwho-1778650
ABSTRACT
Filamentous bacteriophages are natural nanoparticles formed by the self-assembly of structural proteins that have the capability of replication and infection. They are used as a highly efficient vaccine platform to enhance immunogenicity and effectively stimulate the innate and adaptive immune response. Compared with traditional vaccines, phage-based vaccines offer thermodynamic stability, biocompatibility, homogeneity, high carrying capacity, self-assembly, scalability, and low toxicity. This review summarizes recent research on phage-based vaccines in virus prevention. In addition, the expression systems of filamentous phage-based virus vaccines and their application principles are discussed. Moreover, the prospect of the prevention of emerging infectious diseases, such as coronavirus 2019 (COVID-19), is also discussed.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Bacteriophages
/
Viral Vaccines
/
Inovirus
/
Nanoparticles
/
COVID-19
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Nanoscale
Year:
2022
Document Type:
Article
Affiliation country:
D1nr08064d
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