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Comprehensive Review of Cardiovascular Complications of Coronavirus Disease 2019 and Beneficial Treatments.
Welty, Francine K; Rajai, Nazanin; Amangurbanova, Maral.
  • Welty FK; From the Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
  • Rajai N; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Amangurbanova M; From the Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Cardiol Rev ; 30(3): 145-157, 2022.
Article in English | MEDLINE | ID: covidwho-1778952
ABSTRACT
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 and was first reported in December 2019 in Wuhan, China. Since then, it caused a global pandemic with 212,324,054 confirmed cases and 4,440,840 deaths worldwide as of August 22, 2021. The disease spectrum of COVID-19 ranges from asymptomatic subclinical infection to clinical manifestations predominantly affecting the respiratory system. However, it is now evident that COVID-19 is a multiorgan disease with a broad spectrum of manifestations leading to multiple organ injuries including the cardiovascular system. We review studies that have shown that the relationship between cardiovascular diseases and COVID-19 is indeed bidirectional, implicating that preexisting cardiovascular comorbidities increase the morbidity and mortality of COVID-19, and newly emerging cardiac injuries occur in the settings of acute COVID-19 in patients with no preexisting cardiovascular disease. We present the most up-to-date literature summary to explore the incidence of new-onset cardiac complications of coronavirus and their role in predicting the severity of COVID-19. We review the association of elevated troponin with the severity of COVID-19 disease, which includes mild compared to severe disease, in nonintensive care unit compared to intensive care unit patients and in those discharged from the hospital compared to those who die. The role of serum troponin levels in predicting prognosis are compared in survivors and non-survivors. The association between COVID-19 disease and myocarditis, heart failure and coagulopathy are reviewed. Finally, an update on beneficial treatments is discussed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / COVID-19 / Heart Diseases / Myocarditis Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Cardiol Rev Journal subject: Vascular Diseases / Cardiology Year: 2022 Document Type: Article Affiliation country: CRD.0000000000000422

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / COVID-19 / Heart Diseases / Myocarditis Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Cardiol Rev Journal subject: Vascular Diseases / Cardiology Year: 2022 Document Type: Article Affiliation country: CRD.0000000000000422