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Effect of chronic hydroxychloroquine use on COVID-19 risk in patients with rheumatoid arthritis and systemic lupus erythematosus: a multicenter retrospective cohort.
Walbi, Ismail A; Albarqi, Hassan A; Alghanim, Nayef Saleh; Albadi, Marzooq Abdullah; Al Maimouni, Hesham Mohammed; Alkahtani, Saad Ahmed; Alshabi, Ali Mohamed; Alali, Amer S; Alqahtani, Faleh; Al-Najjar, Amal Hassan; Hazzazi, Mohammad A; Alanazi, Deemah S; Sabei, Abdulrahman Abdulaziz; Alsaweed, Omer S; Alajra, Rahaf K; Alqhtani, Hussain.
  • Walbi IA; Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
  • Albarqi HA; Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia.
  • Alghanim NS; Consultant, Rheumatology Department, King Saud Medical City, Riyadh, Saudi Arabia.
  • Albadi MA; Consultant internist and rheumatologist, Security Forces Hospital Program, Riyadh, Saudi Arabia.
  • Al Maimouni HM; Consultant, Rheumatology, Division of Rheumatology, Department of Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
  • Alkahtani SA; Assistant Professor of Medicine, King Saud Bin Abdulaziz University of Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.
  • Alshabi AM; Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
  • Alali AS; Department of Clinical Pharmacy, College of Pharmacy, Najran University, Najran, Saudi Arabia.
  • Alqahtani F; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj, 11942, Saudi Arabia.
  • Al-Najjar AH; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Hazzazi MA; Drug & Poison Information Center Supervisor, Security Forces Hospital Program, Riyadh, Saudi Arabia.
  • Alanazi DS; Assistant Professor of Medicine, King Saud Bin Abdulaziz University of Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.
  • Sabei AA; Vitreoretinal Division, Department of Vitreoretinal, King Abdulaziz Medical City, Riyadh, Saudi Arabia.
  • Alsaweed OS; Senior Pharmacist, Pharmaceutical Care Services, King Saud Medical City, Riyadh, Saudi Arabia.
  • Alajra RK; Senior Registrar, Ministry of Health, First Health cluster, Western Riyadh Dental Complex, Periodontic Division, Riyadh, Saudi Arabia.
  • Alqhtani H; Laboratory Services, Security Forces Hospital Program, Riyadh, Saudi Arabia.
J Int Med Res ; 50(4): 3000605221090363, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1779533
ABSTRACT

OBJECTIVE:

Hydroxychloroquine (HCQ) has been used during the coronavirus disease 2019 (COVID-19) pandemic because of its reported anti-viral activity. This study examined the association of chronic HCQ use with the incidence and complications of COVID-19.

METHODS:

This retrospective cohort study included adults with rheumatoid arthritis and/or systemic lupus erythematosus who visited rheumatology clinics in three tertiary hospitals in Riyadh, Saudi Arabia between January 2019 and December 2020. Patients were categorized into two groups based on HCQ use. Data were obtained from the electronic health record and by interviews with patients. The primary study objective was the incidence of COVID-19 and its complications from March 2020 to February 2021.

RESULTS:

Almost 11% of the study cohort was positive for COVID-19, and the incidence of COVID-19 was similar between HCQ users (11.11%) and nonusers (10.86%). Disease complication rates were similar in the study arms, and they mainly included fever, dry cough, fatigue, and breathing difficulty.

CONCLUSIONS:

This study revealed no significant association between chronic HCQ use and the incidence of COVID-19, and disease complications were similar in the study arms.
Subject(s)
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Antirheumatic Agents / COVID-19 / Lupus Erythematosus, Systemic Type of study: Controlled clinical trial / Etiology study / Observational study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adult / Humans Language: English Journal: J Int Med Res Year: 2022 Document Type: Article Affiliation country: 03000605221090363

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Antirheumatic Agents / COVID-19 / Lupus Erythematosus, Systemic Type of study: Controlled clinical trial / Etiology study / Observational study / Randomized controlled trials / Risk factors Topics: Long Covid Limits: Adult / Humans Language: English Journal: J Int Med Res Year: 2022 Document Type: Article Affiliation country: 03000605221090363