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IgA nephropathy relapse following COVID-19 vaccination treated with corticosteroid therapy: case report.
Watanabe, Shota; Zheng, Shuling; Rashidi, Arash.
  • Watanabe S; Internal Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, 11100 Euclid Ave, Cleveland, OH, 44106, USA. watshoi555@gmail.com.
  • Zheng S; Pathology, University Hospitals Cleveland Medical Center, Cleveland, USA.
  • Rashidi A; Nephrology, University Hospitals Cleveland Medical Center, Cleveland, USA.
BMC Nephrol ; 23(1): 135, 2022 04 07.
Article in English | MEDLINE | ID: covidwho-1779614
ABSTRACT

BACKGROUND:

The flare of immune-mediated disease following coronavirus disease of 2019 (COVID-19) vaccination is a rare adverse event following immunization. De novo, as well as relapsing IgA nephropathy (IgAN) cases, have been reported following either mRNA-1273 (Moderna) or BNT162b2 (Pfizer-BioNTech) vaccination. To our knowledge, the majority of IgAN relapses did not result in severe acute kidney injury (AKI) and resolved spontaneously. CASE PRESENTATION This is a case of a 54-year-old female with a previous diagnosis of IgAN who developed IgAN relapse following the second dose of Moderna vaccine. Gross hematuria developed 2 days after vaccination, which was accompanied by significant AKI. Kidney biopsy showed mild tubular atrophy and IgA staining in mesangium without crescent formation. Significant improvement in serum creatinine (Cr) was observed on day 10 after initiating prednisone. Cr came back to normal within 3 months after initiating corticosteroid.

CONCLUSION:

COVID-19 vaccination is associated with a flare of IgAN that may cause significant AKI. Steroid therapy is associated with recovery. IgAN flare after COVID-19 vaccination should be closely monitored to elucidate any adverse effect associated with the novel vaccine.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 / Glomerulonephritis, IGA Type of study: Case report / Diagnostic study / Observational study Topics: Long Covid / Vaccines Limits: Female / Humans / Middle aged Language: English Journal: BMC Nephrol Journal subject: Nephrology Year: 2022 Document Type: Article Affiliation country: S12882-022-02769-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 / Glomerulonephritis, IGA Type of study: Case report / Diagnostic study / Observational study Topics: Long Covid / Vaccines Limits: Female / Humans / Middle aged Language: English Journal: BMC Nephrol Journal subject: Nephrology Year: 2022 Document Type: Article Affiliation country: S12882-022-02769-9