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Clinical characteristics and predictors of death among hospitalized patients infected with SARS-CoV-2 in Sicily, Italy: A retrospective observational study.
Cosentino, Federica; Moscatt, Vittoria; Marino, Andrea; Pampaloni, Alessio; Scuderi, Daniele; Ceccarelli, Manuela; Benanti, Francesco; Gussio, Maria; Larocca, Licia; Boscia, Vincenzo; Vinci, Giovanni; Zagami, Aldo; Onorante, Anna; Lupo, Gaetano; Torrisi, Salvatore; Grasso, Silvana; Bruno, Roberto; Iacobello, Carmelo; Bonfante, Salvatore; Guarneri, Luigi; Cascio, Antonio; Franco, Antonella; Del Vecchio, Rossella Fontana; Di Rosolini, Maria Antonietta; Pulvirenti, Alfredo; Larnè, Damiano; Nunnari, Giuseppe; Celesia, Benedetto Maurizio; Cacopardo, Bruno.
  • Cosentino F; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Moscatt V; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Marino A; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Pampaloni A; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Scuderi D; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Ceccarelli M; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Benanti F; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Gussio M; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Larocca L; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Boscia V; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Vinci G; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Zagami A; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Onorante A; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Lupo G; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Torrisi S; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Grasso S; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Bruno R; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Iacobello C; Infectious Disease Unit, Cannizzaro Hospital, I-95126 Catania, Italy.
  • Bonfante S; Infectious Diseases Unit, Gravina Hospital, I-95041 Caltagirone, Catania, Italy.
  • Guarneri L; Infectious Diseases Unit, Enna Hospital, I-94100 Enna, Italy.
  • Cascio A; Infectious and Tropical Diseases Unit, Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, I-90127 Palermo, Italy.
  • Franco A; Infectious Diseases Unit, Siracusa Hospital, I-96100 Siracusa, Italy.
  • Del Vecchio RF; Infectious Diseases Unit, Siracusa Hospital, I-96100 Siracusa, Italy.
  • Di Rosolini MA; Infectious and Tropical Diseases Unit, Modica Hospital, I-97015 Ragusa, Italy.
  • Pulvirenti A; Bioinformatics Section, Department of Clinical and Experimental Medicine, University of Catania, I-95125 Catania, Italy.
  • Larnè D; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, I-98124 Messina, Italy.
  • Nunnari G; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, I-98124 Messina, Italy.
  • Celesia BM; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
  • Cacopardo B; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Nesima Hospital, University of Catania, I-95122 Catania, Italy.
Biomed Rep ; 16(5): 34, 2022 May.
Article in English | MEDLINE | ID: covidwho-1780104
ABSTRACT
Since late December 2019, severe acute respiratory syndrome coronavirus 2 has spread across the world, which resulted in the World Health Organization declaring a global pandemic. Coronavirus disease 2019 (COVID-19) presents a highly variable spectrum with regard to the severity of illness. Most infected individuals exhibit a mild to moderate illness (81%); however, 14% have a serious disease and 5% develop severe acute respiratory distress syndrome (ARDS), requiring intensive care support. The mortality rate of COVID-19 continues to rise across the world. Data regarding predictors of mortality in patients with COVID 19 are still scarce but are being actively investigated. The present multicenter retrospective observational study provides a complete description of the demographic and clinical characteristics, comorbidities and laboratory abnormalities in a population of 421 hospitalized patients recruited across eight infectious disease units in Southern Italy (Sicily) with the aim of identifying the baseline characteristics predisposing COVID-19 patients to critical illness or death. In this study, older age, pre-existing comorbidities and certain changes in laboratory markers (such as neutrophilia, lymphocytopenia and increased C-reactive protein levels) at the time of admission were associated with a higher risk of mortality. Male sex, on the other hand, was not significantly associated with increased risk of mortality. Symptoms such as fatigue, older age, a number of co-pathologies and use of continuous positive airway pressure were the most significant contributors in the estimation of clinical prognosis. Further research is required to better characterize the epidemiological features of COVID-19, to understand the related predictors of death and to develop new effective therapeutic strategies.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Long Covid Language: English Journal: Biomed Rep Year: 2022 Document Type: Article Affiliation country: Br.2022.1517

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Topics: Long Covid Language: English Journal: Biomed Rep Year: 2022 Document Type: Article Affiliation country: Br.2022.1517