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Prevalence and patterns of symptoms of dysautonomia in patients with long-COVID syndrome: A cross-sectional study.
Eldokla, Ahmed M; Mohamed-Hussein, Aliae A; Fouad, Ahmed M; Abdelnaser, Mariam G; Ali, Sara T; Makhlouf, Nahed A; Sayed, Islam G; Makhlouf, Hoda A; Shah, Jaffer; Aiash, Hani.
  • Eldokla AM; Department of Neurology, State University of New York, Upstate Medical University, Syracuse, New York, 13210, USA.
  • Mohamed-Hussein AA; Department of Pathology, State University of New York, Upstate Medical University, Syracuse, New York, 13210, USA.
  • Fouad AM; Chest Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Abdelnaser MG; Department of Public Health, Occupational and Environmental Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
  • Ali ST; Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Makhlouf NA; Department of Neurology, State University of New York, Upstate Medical University, Syracuse, New York, 13210, USA.
  • Sayed IG; Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Makhlouf HA; Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Shah J; Chest Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
  • Aiash H; New York State Department of Health, Albany, New York, USA.
Ann Clin Transl Neurol ; 9(6): 778-785, 2022 06.
Article in English | MEDLINE | ID: covidwho-1782552
ABSTRACT

BACKGROUND:

The association between autonomic dysfunction and long-COVID syndrome is established. However, the prevalence and patterns of symptoms of dysautonomia in long-COVID syndrome in a large population are lacking.

OBJECTIVE:

To evaluate the prevalence and patterns of symptoms of dysautonomia in patients with long-COVID syndrome.

METHODS:

We administered the Composite Autonomic Symptom Score 31 (COMPASS-31) questionnaire to a sample of post-COVID-19 patients who were referred to post-COVID clinic in Assiut University Hospitals, Egypt for symptoms concerning for long-COVID syndrome. Participants were asked to complete the COMPASS-31 questionnaire referring to the period of more than 4 weeks after acute COVID-19.

RESULTS:

We included 320 patients (35.92 ± 11.92 years, 73% females). The median COMPASS-31 score was 26.29 (0-76.73). The most affected domains of dysautonomia were gastrointestinal, secretomotor, and orthostatic intolerance with 91.6%, 76.4%, and 73.6%, respectively. There was a positive correlation between COMPASS-31 score and long-COVID duration (p < 0.001) and a positive correlation between orthostatic intolerance domain score and post-COVID duration (p < 0.001). There was a positive correlation between orthostatic intolerance domain score and age of participants (p = 0.004). Two hundred forty-seven patients (76.7%) had a high score of COMPASS-31 >16.4. Patients with COMPASS-31 >16.4 had a longer duration of long-COVID syndrome than those with score <16.4 (46.2 vs. 26.8 weeks, p < 0.001).

CONCLUSIONS:

Symptoms of dysautonomia are common in long-COVID syndrome. The most common COMPASS-31 affected domains of dysautonomia are gastrointestinal, secretomotor, and orthostatic intolerance. There is a positive correlation between orthostatic intolerance domain score and patients' age.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Primary Dysautonomias / Orthostatic Intolerance / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Ann Clin Transl Neurol Year: 2022 Document Type: Article Affiliation country: Acn3.51557

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Primary Dysautonomias / Orthostatic Intolerance / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Ann Clin Transl Neurol Year: 2022 Document Type: Article Affiliation country: Acn3.51557