Lipid rafts as viral entry routes and immune platforms: A double-edged sword in SARS-CoV-2 infection?
Biochim Biophys Acta Mol Cell Biol Lipids
; 1867(6): 159140, 2022 06.
Article
in English
| MEDLINE | ID: covidwho-1783190
ABSTRACT
Lipid rafts are nanoscopic compartments of cell membranes that serve a variety of biological functions. They play a crucial role in viral infections, as enveloped viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can exploit rafts to enter or quit target cells. On the other hand, lipid rafts contribute to the formation of immune synapses and their proper functioning is a prerequisite for adequate immune response and viral clearance. In this narrative review we dissect the panorama focusing on this singular aspect of cell biology in the context of SARS-CoV-2 infection and therapy. A lipid raft-mediated mechanism can be hypothesized for many drugs recommended or considered for the treatment of SARS-CoV-2 infection, such as glucocorticoids, antimalarials, immunosuppressants and antiviral agents. Furthermore, the additional use of lipid-lowering agents, like statins, may affect the lipid composition of membrane rafts and thus influence the processes occurring in these compartments. The combination of drugs acting on lipid rafts may be successful in the treatment of more severe forms of the disease and should be reserved for further investigation.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Internalization
/
COVID-19 Drug Treatment
Type of study:
Reviews
Limits:
Humans
Language:
English
Journal:
Biochim Biophys Acta Mol Cell Biol Lipids
Year:
2022
Document Type:
Article
Affiliation country:
J.bbalip.2022.159140
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