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Long-term asymptomatic SARS-CoV-2 infection associated with deficiency on multiple immune cells.
He, Gang; Chuai, Xia; Liang, Dan; Chen, Chunyu; Hu, Changzheng; Ke, Changwen; Ke, Bixia; Zhen, Peilin; Zhang, Huajun.
  • He G; Jiangmen Central Hospital affiliated with Jiangmen Hospital of Sun Yat-Sen University, Jiangmen 529000, China.
  • Chuai X; Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang, Hebei 050017, China.
  • Liang D; Guangdong Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Chen C; Jiangmen Central Hospital affiliated with Jiangmen Hospital of Sun Yat-Sen University, Jiangmen 529000, China.
  • Hu C; Jiangmen Central Hospital affiliated with Jiangmen Hospital of Sun Yat-Sen University, Jiangmen 529000, China.
  • Ke C; Guangdong Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Ke B; Guangdong Center for Disease Control and Prevention, Guangzhou 511430, China.
  • Zhen P; Jiangmen Central Hospital affiliated with Jiangmen Hospital of Sun Yat-Sen University, Jiangmen 529000, China.
  • Zhang H; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China.
Biosaf Health ; 4(3): 205-208, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1783215
ABSTRACT
The immune responses and the function of immune cells among asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection cases, especially in immuno-compromised individuals, remain largely unknown. Here we present a case of asymptomatic SARS-CoV-2 infection that lasted for at least 67 days. The patient has administrated Thymalfasin as 1.6 mg per dose every other day from Day 45 to 70, plus 200 mg per dose Arbidol antiviral therapy three doses per day from Day 48 to 57. Throughout the infection, no anti-SARS-CoV-2 specific IgM or IgG antibodies were detected. Instead, the patient showed either a low percentage or an absolute number of non-classical monocytes, dendritic cells (DCs), CD4+ T cells, and regulatory T cells (Tregs), which may account for the clinical feature and absence of antibody response. This case may shed new light on the outbreak management related to control/prevention, treatment, and vaccination of SARS-CoV-2 and other virus infections in immunocompromised individuals.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Observational study / Prognostic study Topics: Vaccines Language: English Journal: Biosaf Health Year: 2022 Document Type: Article Affiliation country: J.bsheal.2022.04.001

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Observational study / Prognostic study Topics: Vaccines Language: English Journal: Biosaf Health Year: 2022 Document Type: Article Affiliation country: J.bsheal.2022.04.001