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Assessment of BIV1-CovIran inactivated vaccine-elicited neutralizing antibody against the emerging SARS-CoV-2 variants of concern.
Salehi, Mohammadreza; Hosseini, Hamed; Jamshidi, Hamid Reza; Jalili, Hasan; Tabarsi, Payam; Mohraz, Minoo; Karimi, Hesam; Lotfinia, Majid; Aalizadeh, Reza; Mohammadi, Mehrdad; Ramazi, Shahin; Abdoli, Asghar.
  • Salehi M; Infectious Diseases Department, Tehran University of Medical Sciences, Tehran, Iran.
  • Hosseini H; Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.
  • Jamshidi HR; Department of Pharmacology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Jalili H; Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.
  • Tabarsi P; Department of Infectious Disease, Clinical Tuberculosis and Epidemiology Research Center, Shahid Beheshti University of Medical Sciences Tehran, Iran.
  • Mohraz M; Iranian Research Center for HIV/AIDS, Tehran University of Medical Sciences Tehran, Iran.
  • Karimi H; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
  • Lotfinia M; Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran.
  • Aalizadeh R; Department of Biochemistry, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran.
  • Mohammadi M; Department of Microbiology and Immunology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
  • Ramazi S; Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
  • Abdoli A; Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran; Amirabad Virology Laboratory, Vaccine Unit, Tehran, Iran. Electronic address: asghar.abdoli7@gmail.com.
Clin Microbiol Infect ; 28(6): 882.e1-882.e7, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1783261
ABSTRACT

OBJECTIVES:

The BIV1-CovIran vaccine is highly effective against COVID-19. The neutralizing potency of all SARS-CoV-2 vaccines seems to be decreased against variants of concern. We assessed the sensitivity of the Alpha (B.1.1.7), Beta (B.1.351), and Delta (B.1.617.2) variants to neutralizing antibodies (NAbs) present in sera from individuals who had received the BIV1-CovIran candidate vaccine compared with an original Wuhan-related strain.

METHODS:

The ability of vaccine serum to neutralize the variants was measured using the conventional virus neutralization test. The correlation of spike (S) protein antibody and anti-receptor binding domain with neutralizing activity was investigated.

RESULTS:

The current study demonstrated that 29 of 32 (90.6%; 95% CI 75.0-98.0) of the vaccinees developed NAbs against a Wuhan-related strain. It is noteworthy that 28 (87.50%) and 24 of 32 (75%) of the recipients were able to produce NAbs against Alpha, Beta, and Delta variants, respectively. Serum virus-neutralizing titres for different SARS-CoV-2 strains were weakly correlated with anti-receptor binding domain antibodies (Spearman r = 36-42, p < 0.05), but not S-binding antibodies (p > 0.05).

DISCUSSION:

Although there was a reduction in neutralization titres against the Alpha, Beta, and Delta variants compared with the Wuhan strain, BIV1-CovIran still exhibited potent neutralizing activity against the SARS-CoV-2 variants of concern.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2022 Document Type: Article Affiliation country: J.cmi.2022.02.030

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2022 Document Type: Article Affiliation country: J.cmi.2022.02.030