Infection prevention for extremely low birth weight infants in the NICU.
Semin Fetal Neonatal Med
; 27(3): 101345, 2022 06.
Article
in English
| MEDLINE | ID: covidwho-1783752
ABSTRACT
Extremely preterm infants are particularly vulnerable to systemic infections secondary to their immature immune defenses, prolonged hospitalizations, delays in enteral feeding, early antibiotic exposure, and need for life-sustaining invasive interventions. There have been several evidence-based practices for infection prevention in this population, such as human milk feedings, utilization of "bundle checklists" and decolonization of pathogenic organisms. Other practices, such as the use of probiotics, human milk-derived fortifiers, and antifungal prophylaxis are more controversial and require further investigation regarding the risks and benefits of such interventions. This chapter examines the susceptibility of the preterm newborn infant to invasive infections and describes several strategies for infection prevention, along with the associated limitations of such practices. It also addresses the various gaps in our understanding of preventing infections in this population, and the need for additional large multi-center randomized controlled trials. Additionally, the role of the SARs-CoV-2 global pandemic and associated strategies for infection prevention in the NICU are discussed.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Enterocolitis, Necrotizing
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
/
Infant, Newborn
Language:
English
Journal:
Semin Fetal Neonatal Med
Journal subject:
Pediatrics
/
Perinatology
Year:
2022
Document Type:
Article
Affiliation country:
J.siny.2022.101345
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