SINBAD, structural, experimental and clinical characterization of STAT inhibitors and their potential applications.
Sci Data
; 9(1): 139, 2022 03 31.
Article
in English
| MEDLINE | ID: covidwho-1784013
ABSTRACT
The abnormal activation of signal transducer and activator of transcription (STAT) protein family is recognized as cause or driving force behind multiple diseases progression. Therefore, searching for potential treatment strategy is pursued by multiple scientific groups. We consider that providing comprehensive, integrated and unified dataset for STAT inhibitory compounds may serve as important tool for other researchers. We developed SINBAD (STAT INhbitor Biology And Drug-ability) in response to our experience with inhibitory compound research, knowing that gathering detailed information is crucial for effective experiment design and also for finding potential solutions in case of obtaining inconclusive results. SINBAD is a curated database of STAT inhibitors which have been published and described in scientific articles providing prove of their inhibitory properties. It is a tool allowing easy analysis of experimental conditions and provides detailed information about known STAT inhibitory compounds.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Transcription Factors
/
Pharmaceutical Preparations
/
Intracellular Signaling Peptides and Proteins
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
Sci Data
Year:
2022
Document Type:
Article
Affiliation country:
S41597-022-01243-3
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