Antimicrobial effects of microwave plasma-activated water with skin protective effect for novel disinfectants in pandemic era.
Sci Rep
; 12(1): 5968, 2022 04 08.
Article
in English
| MEDLINE | ID: covidwho-1784028
ABSTRACT
Skin antiseptics have important implications for public health and medicine. Although conventional antiseptics have considerable antimicrobial activity, skin toxicity and the development of resistance are common problems. Plasma-treated water has sterilization and tissue-regenerative effects. Therefore, the aim of this study was to identify whether plasma-activated water (PAW) manufactured by our microwave plasma system can be used as a novel antiseptic solution for skin protection. PAW was produced by dissolving reactive nitrogen oxide gas using microwave plasma in deionized water. The antibacterial effects of PAW against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, and Salmonella typhimurium and effective concentrations were investigated by a solid agar plate assay. The factors mediating the effects of PAW were evaluated by the addition of reactive species scavengers. Cytotoxicity and cell viability assays were performed to examine the protective effect of PAW on normal skin cells. PAW exhibited excellent sterilization and no toxicity in normal skin cells. Experiments also confirmed the potential of PAW as a sanitizer for SARS-CoV-2. Our findings support the use of PAW as an effective skin disinfectant with good safety in the current situation of a global pandemic.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Disinfectants
/
COVID-19
/
Anti-Infective Agents, Local
Type of study:
Experimental Studies
Limits:
Humans
Language:
English
Journal:
Sci Rep
Year:
2022
Document Type:
Article
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