Tryptophan regulates Drosophila zinc stores.
Proc Natl Acad Sci U S A
; 119(16): e2117807119, 2022 04 19.
Article
in English
| MEDLINE | ID: covidwho-1784076
ABSTRACT
Zinc deficiency is commonly attributed to inadequate absorption of the metal. Instead, we show that body zinc stores in Drosophila melanogaster depend on tryptophan consumption. Hence, a dietary amino acid regulates zinc status of the whole insecta finding consistent with the widespread requirement of zinc as a protein cofactor. Specifically, the tryptophan metabolite kynurenine is released from insect fat bodies and induces the formation of zinc storage granules in Malpighian tubules, where 3-hydroxykynurenine and xanthurenic acid act as endogenous zinc chelators. Kynurenine functions as a peripheral zinc-regulating hormone and is converted into a 3-hydroxykynureninezincchloride complex, precipitating within the storage granules. Thus, zinc and the kynurenine pathwaywell-known modulators of immunity, blood pressure, aging, and neurodegenerationare physiologically connected.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Tryptophan
/
Zinc
/
Drosophila melanogaster
/
Kynurenine
Limits:
Animals
Language:
English
Journal:
Proc Natl Acad Sci U S A
Year:
2022
Document Type:
Article
Affiliation country:
Pnas.2117807119
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