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COVID-19 severity from Omicron and Delta SARS-CoV-2 variants.
Wrenn, Jesse O; Pakala, Suman B; Vestal, Grant; Shilts, Meghan H; Brown, Hunter M; Bowen, Sara M; Strickland, Britton A; Williams, Timothy; Mallal, Simon A; Jones, Ian D; Schmitz, Jonathan E; Self, Wesley H; Das, Suman R.
  • Wrenn JO; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Pakala SB; Division of Infectious Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Vestal G; Division of Infectious Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Shilts MH; Division of Infectious Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Brown HM; Division of Infectious Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Bowen SM; Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Strickland BA; Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Williams T; Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Mallal SA; Division of Infectious Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Jones ID; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Schmitz JE; Department of Pathology Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Self WH; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
  • Das SR; Division of Infectious Disease, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Influenza Other Respir Viruses ; 16(5): 832-836, 2022 09.
Article in English | MEDLINE | ID: covidwho-1784669
ABSTRACT
The Omicron variant of SARS-CoV-2 achieved worldwide dominance in late 2021. Early work suggests that infections caused by the Omicron variant may be less severe than those caused by the Delta variant. We sought to compare clinical outcomes of infections caused by these two strains, confirmed by whole genome sequencing, over a short period of time, from respiratory samples collected from SARS-CoV-2 positive patients at a large medical center. We found that infections caused by the Omicron variant caused significantly less morbidity, including admission to the hospital and requirement for oxygen supplementation, and significantly less mortality than those caused by the Delta variant.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Humans Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: Irv.12982

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Humans Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: Irv.12982