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Extracellular Vesicles and Acute Kidney Injury: Potential Therapeutic Avenue for Renal Repair and Regeneration.
Kosanovic, Maja; Milutinovic, Bojana; Glamoclija, Sofija; Morlans, Ingrid Mena; Ortiz, Alberto; Bozic, Milica.
  • Kosanovic M; Institute for the Application of Nuclear Energy, INEP, University of Belgrade, 11080 Belgrade, Serbia.
  • Milutinovic B; Department of Neurosurgery, MD Anderson Cancer Center, University of Texas, Houston, TX 77030, USA.
  • Glamoclija S; Institute for the Application of Nuclear Energy, INEP, University of Belgrade, 11080 Belgrade, Serbia.
  • Morlans IM; Vascular and Renal Translational Research Group, Biomedical Research Institute of Lleida Dr. Pifarré Foundation (IRBLleida), 25196 Lleida, Spain.
  • Ortiz A; Department of Nephrology and Hypertension, IIS-Fundación Jiménez Díaz, Universidad Autónoma Madrid, 28040 Madrid, Spain.
  • Bozic M; Vascular and Renal Translational Research Group, Biomedical Research Institute of Lleida Dr. Pifarré Foundation (IRBLleida), 25196 Lleida, Spain.
Int J Mol Sci ; 23(7)2022 Mar 30.
Article in English | MEDLINE | ID: covidwho-1785735
ABSTRACT
Acute kidney injury (AKI) is a sudden decline of renal function and represents a global clinical problem due to an elevated morbidity and mortality. Despite many efforts, currently there are no treatments to halt this devastating condition. Extracellular vesicles (EVs) are nanoparticles secreted by various cell types in both physiological and pathological conditions. EVs can arise from distinct parts of the kidney and can mediate intercellular communication between various cell types along the nephron. Besides their potential as diagnostic tools, EVs have been proposed as powerful new tools for regenerative medicine and have been broadly studied as therapeutic mediators in different models of experimental AKI. In this review, we present an overview of the basic features and biological relevance of EVs, with an emphasis on their functional role in cell-to-cell communication in the kidney. We explore versatile roles of EVs in crucial pathophysiological mechanisms contributing to AKI and give a detailed description of the renoprotective effects of EVs from different origins in AKI. Finally, we explain known mechanisms of action of EVs in AKI and provide an outlook on the potential clinical translation of EVs in the setting of AKI.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / Mesenchymal Stem Cells / Extracellular Vesicles Type of study: Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / Mesenchymal Stem Cells / Extracellular Vesicles Type of study: Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article