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Dermal Delivery of a SARS-CoV-2 Subunit Vaccine Induces Immunogenicity against Variants of Concern.
McMillan, Christopher L D; Azuar, Armira; Choo, Jovin J Y; Modhiran, Naphak; Amarilla, Alberto A; Isaacs, Ariel; Honeyman, Kate E; Cheung, Stacey T M; Liang, Benjamin; Wurm, Maria J; Pino, Paco; Kint, Joeri; Fernando, Germain J P; Landsberg, Michael J; Khromykh, Alexander A; Hobson-Peters, Jody; Watterson, Daniel; Young, Paul R; Muller, David A.
  • McMillan CLD; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Azuar A; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Choo JJY; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Modhiran N; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Amarilla AA; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Isaacs A; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Honeyman KE; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Cheung STM; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Liang B; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Wurm MJ; ExcellGene SA, CH1870 Monthey, Switzerland.
  • Pino P; ExcellGene SA, CH1870 Monthey, Switzerland.
  • Kint J; ExcellGene SA, CH1870 Monthey, Switzerland.
  • Fernando GJP; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Landsberg MJ; Translational Research Institute, Vaxxas Pty Ltd., Brisbane, QLD 4102, Australia.
  • Khromykh AA; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Hobson-Peters J; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, QLD 4072 and 4029, Australia.
  • Watterson D; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
  • Young PR; Australian Infectious Diseases Research Centre, Global Virus Network Centre of Excellence, Brisbane, QLD 4072 and 4029, Australia.
  • Muller DA; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Vaccines (Basel) ; 10(4)2022 Apr 08.
Article in English | MEDLINE | ID: covidwho-1786092
ABSTRACT
The ongoing coronavirus disease 2019 (COVID-19) pandemic continues to disrupt essential health services in 90 percent of countries today. The spike (S) protein found on the surface of the causative agent, the SARS-CoV-2 virus, has been the prime target for current vaccine research since antibodies directed against the S protein were found to neutralize the virus. However, as new variants emerge, mutations within the spike protein have given rise to potential immune evasion of the response generated by the current generation of SARS-CoV-2 vaccines. In this study, a modified, HexaPro S protein subunit vaccine, delivered using a needle-free high-density microarray patch (HD-MAP), was investigated for its immunogenicity and virus-neutralizing abilities. Mice given two doses of the vaccine candidate generated potent antibody responses capable of neutralizing the parental SARS-CoV-2 virus as well as the variants of concern, Alpha and Delta. These results demonstrate that this alternative vaccination strategy has the potential to mitigate the effect of emerging viral variants.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10040578

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10040578