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The Association Between the Albumin and Viral Negative Conversion Rate in Patients Infected with Novel Coronavirus Disease 2019 (COVID-19).
Lang, Li-Wei; Zhu, Zhen-Zhen; Xu, Zhe; Zhu, Shan-Wei; Meng, Peng; Wang, Hong-Yan; Song, Zhan-Dong; Wang, Ying; Bi, Jing-Feng.
  • Lang LW; Clinical Trial Research Center, Department of Pharmacy, Medical Supplies Center of PLA General Hospital, Beijing, 100039, People's Republic of China.
  • Zhu ZZ; Clinical Trial Research Center, Department of Pharmacy, Medical Supplies Center of PLA General Hospital, Beijing, 100039, People's Republic of China.
  • Xu Z; Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, 100039, People's Republic of China.
  • Zhu SW; Clinical Trial Research Center, Department of Pharmacy, Medical Supplies Center of PLA General Hospital, Beijing, 100039, People's Republic of China.
  • Meng P; Department of Outpatient, Zi-Bo Central Hospital of Shan Dong, Shan Dong, 255036, People's Republic of China.
  • Wang HY; Clinical Trial Research Center, Department of Pharmacy, Medical Supplies Center of PLA General Hospital, Beijing, 100039, People's Republic of China.
  • Song ZD; Clinical Trial Research Center, Department of Pharmacy, Medical Supplies Center of PLA General Hospital, Beijing, 100039, People's Republic of China.
  • Wang Y; Respiratory Department No. 960 Hospital, The People's Liberation Army, Jinan, 250014, People's Republic of China.
  • Bi JF; Clinical Trial Research Center, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, 100039, People's Republic of China.
Infect Drug Resist ; 15: 1687-1694, 2022.
Article in English | MEDLINE | ID: covidwho-1938523
ABSTRACT

Purpose:

The novel coronavirus disease 2019 (COVID-19) epidemic is the severe global pandemic with large numbers of infected cases and deaths in recent decades. The previous studies were all about the influence of albumin (ALB) for the severity and mortality of in-patients infected with COVID-19. But few studies exist about the influence factors to achieve viral negative conversion. Therefore, this study conducted an exploratory study to investigate the effect of albumin on negative conversion rate.

Methods:

Among the 190 hospitalized patients with moderate COVID-19 who had a course of disease longer than 30 days, 102 achieved viral negative conversion in 30-45 days and 88 not after 45 days. Taking other variables as concomitant variable, Cox proportional hazard regression model was applied to explore the influence of albumin to negative conversion rate under various factors.

Results:

By comparing patients who could and could not achieve the finally viral negative conversion, a possible nonlinear relationship between the continuous variables and clinical outcomes was examined by a restricted cubic spline regression model. An association was found between albumin levels and hazard ratio of viral negative conversion rate (P = 0.027). The increase of albumin was accompanied with decreases of hazard ratio of viral negative conversion rate (the value of albumin <38 g/L). But when the value of albumin was higher than 38 g/L, the hazard ratio of viral negative conversion rate approached 1, it means that albumin is not a risk factor for the viral negative conversion rate of COVID-19 disease.

Conclusion:

For patients with COVID-19, albumin is a common and observed laboratory parameter. It is associated with final viral negative conversion rate although its underlying mechanism and relationship with the viral negative conversion rate still need to be clarified.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Infect Drug Resist Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Infect Drug Resist Year: 2022 Document Type: Article