Evolutionary analysis of mammalian ACE2 and the key residues involved in binding to the Spike protein revealed potential SARS-CoV-2 hosts

Lopes, L. R.; Lucca Pina, N. C. de, Silva Junior, A. C. da, Paiva, P. B.

Lopes, L. R.; Lucca Pina, N. C. de, Silva Junior, A. C. da, Paiva, P. B..

Journal of Medical Microbiology and Infectious Diseases ; 10(1):1-9, 2022.

Article in English | CAB Abstracts | ID: covidwho-1787279

ABSTRACT

ABSTRACT

Introduction:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) spilled over to humans via wild mammals, entering the host cell using angiotensin-converting enzyme 2 (ACE2) as receptor through Spike (S) protein binding. While SARS-CoV-2 became fully adapted to humans and globally spread, some mammal species were infected back. The present study evaluated the potential risk of mammals becoming hosts for SARS-CoV-2 through bioinformatics prediction based on ACE2 receptors.

Keywords

Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Pets and Companion Animals [LL070]; Pathogens, Parasites and Infectious Diseases (Wild Animals) [YY700]; Prion, Viral, Bacterial and Fungal Pathogens of Animals [LL821]; Biochemistry and Physiology of Microorganisms [ZZ394]; Genetics and Molecular Biology of Microorganisms [ZZ395]; Molecular Biology and Molecular Genetics [ZZ360]; Taxonomy and Evolution [ZZ380]; coronavirus disease 2019; viral diseases; human diseases; pandemics; angiotensin-converting enzyme 2; binding; domestic animals; evolution; infectious diseases; livestock; molecular genetics; molecular taxonomy; outbreaks; pets; phylogeny; proteins; receptors; residues; surveillance; susceptibility; taxonomy; water; wild animals; Severe acute respiratory syndrome coronavirus 2; mammals; man; Cetacea; pigs; Primates; rabbits; rodents; Severe acute respiratory syndrome coronavirus; cattle; horses; Equidae; Equus; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; vertebrates; Chordata; animals; eukaryotes; Homo; Hominidae; Sus scrofa; Sus; Suidae; Suiformes; Artiodactyla; Leporidae; Lagomorpha; Bos; Bovidae; ruminants; Perissodactyla; Coronavirus; SARS-CoV-2; viral infections; communicable diseases; biochemical genetics; pet animals; swine; hogs; systematics

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Collection: Databases of international organizations Database: CAB Abstracts Language: English Journal: Journal of Medical Microbiology and Infectious Diseases Year: 2022 Document Type: Article

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