Kampo Medicine Promotes Early Recovery From Coronavirus Disease 2019-Related Olfactory Dysfunction: A Retrospective Observational Study
Frontiers in pharmacology
; 13, 2022.
Article
in English
| EuropePMC | ID: covidwho-1787353
ABSTRACT
Background:
Olfactory dysfunction is a common symptom in patients with coronavirus disease 2019, and it significantly deteriorates patients’ quality of life. Effective treatments remain unknown.Purpose:
To assess the effect of Japanese traditional (Kampo) medicine on coronavirus disease 2019-related olfactory dysfunction. StudyDesign:
Retrospective observational study.Methods:
In total, 87 patients aged ≥18 years with coronavirus disease 2019 and severe dysosmia or anosmia (Numeric Rating Scale, ≥7) at isolation facilities in Miyagi Prefecture, Japan, were enrolled from October 2020 to March 2021. Patients were divided into the Kampo group (N = 52) and the control group (N = 35) based on the treatment received. Changes in Numeric Rating Scale scores were evaluated at the first visit and 2 weeks after.Results:
The median reduction in the olfactory dysfunction score at both 1 and 2 weeks after the first visit was significantly greater in the Kampo group (6 and 8, respectively;p = 0.03) than in the control group (3 and 7, respectively;p = 0.04). We defined improvement in olfactory dysfunction as a median reduction in the olfactory dysfunction score of ≥5. Multiple logistic regression analysis demonstrated that only Kampo treatment was significantly associated with improvement in olfactory dysfunction.Conclusion:
This study suggests that Kampo medication promotes early recovery from coronavirus disease 2019-related olfactory dysfunction.
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Collection:
Databases of international organizations
Database:
EuropePMC
Type of study:
Observational study
/
Prognostic study
Topics:
Traditional medicine
Language:
English
Journal:
Frontiers in pharmacology
Year:
2022
Document Type:
Article
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