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Persistent COVID-19 symptoms in a community study of 606,434 people in England.
Whitaker, Matthew; Elliott, Joshua; Chadeau-Hyam, Marc; Riley, Steven; Darzi, Ara; Cooke, Graham; Ward, Helen; Elliott, Paul.
  • Whitaker M; School of Public Health, Imperial College London, London, UK.
  • Elliott J; MRC Centre for Environment and Health, Imperial College London, London, UK.
  • Chadeau-Hyam M; Imperial College Healthcare NHS Trust, London, UK.
  • Riley S; Department of Infectious Disease, Imperial College London, London, UK.
  • Darzi A; School of Public Health, Imperial College London, London, UK.
  • Cooke G; MRC Centre for Environment and Health, Imperial College London, London, UK.
  • Ward H; School of Public Health, Imperial College London, London, UK.
  • Elliott P; MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, UK.
Nat Commun ; 13(1): 1957, 2022 04 12.
Article in English | MEDLINE | ID: covidwho-1788285
ABSTRACT
Long COVID remains a broadly defined syndrome, with estimates of prevalence and duration varying widely. We use data from rounds 3-5 of the REACT-2 study (n = 508,707; September 2020 - February 2021), a representative community survey of adults in England, and replication data from round 6 (n = 97,717; May 2021) to estimate the prevalence and identify predictors of persistent symptoms lasting 12 weeks or more; and unsupervised learning to cluster individuals by reported symptoms. At 12 weeks in rounds 3-5, 37.7% experienced at least one symptom, falling to 21.6% in round 6. Female sex, increasing age, obesity, smoking, vaping, hospitalisation with COVID-19, deprivation, and being a healthcare worker are associated with higher probability of persistent symptoms in rounds 3-5, and Asian ethnicity with lower probability. Clustering analysis identifies a subset of participants with predominantly respiratory symptoms. Managing the long-term sequelae of COVID-19 will remain a major challenge for affected individuals and their families and for health services.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Country/Region as subject: Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-29521-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans Country/Region as subject: Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-29521-z