Platelet-leukocyte interactions in the pathogenesis of viral infections.
Platelets
; 33(2): 200-207, 2022 Feb 17.
Article
in English
| MEDLINE | ID: covidwho-1788406
ABSTRACT
Evolving evidence demonstrates that platelets have major roles in viral syndromes through previously unrecognized viral sensing and effector functions. Activated platelets and increased platelet-leukocyte aggregates are observed in clinical and experimental viral infections. The mechanisms and outcomes of platelet-leukocyte interactions depend on the interacting leukocyte as well as on the pathogen and pathological conditions. In this review, we discuss the mechanisms involved in platelet interactions with leukocytes and its functions during viral infections. We focus on the contributions of human platelet-leukocyte interactions to pathophysiological and protective responses during viral infections of major global health relevance, including acquired immunodeficiency syndrome (AIDS), dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), influenza pneumonia, and COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Blood Platelets
/
Virus Diseases
/
Leukocytes
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Platelets
Journal subject:
Hematology
Year:
2022
Document Type:
Article
Affiliation country:
09537104.2021.1952179
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