Alterations in platelets during SARS-CoV-2 infection.
Platelets
; 33(2): 192-199, 2022 Feb 17.
Article
in English
| MEDLINE | ID: covidwho-1788407
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a pandemic syndrome caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 infection induces a process of inflammation and thrombosis supported by an altered platelet activation state. This platelet activation is peculiar being characterized by the formation of platelet-leukocytes rather than platelet-platelet aggregates and by an increased procoagulant potential supported by elevated levels of TF positive platelets and microvesicles.Therapeutic strategies targeting, beyond systemic inflammation (i.e. with tocilizumab, an anti interleukin-6 receptor), this state of platelet activation might therefore be beneficial. Among the antithrombotic drugs proposed as candidates to treat patients with SARS-CoV-2 infection, antiplatelet drugs, such as aspirin are showing promising results.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Blood Platelets
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Platelets
Journal subject:
Hematology
Year:
2022
Document Type:
Article
Affiliation country:
09537104.2021.1962519
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