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In vivo antiviral effect of plant essential oils against avian infectious bronchitis virus.
Zhang, Yu; Li, Xiao-Yan; Zhang, Bing-Sha; Ren, Li-Na; Lu, Yan-Peng; Tang, Jin-Wen; Lv, Di; Yong, Lu; Lin, Li-Ting; Lin, Zi-Xue; Mo, Qin; Mo, Mei-Lan.
  • Zhang Y; College of Animal Science and Technology, Guangxi University, Nanning, 530004, China.
  • Li XY; College of Animal Science and Technology, Guangxi University, Nanning, 530004, China.
  • Zhang BS; College of Animal Science and Technology, Guangxi University, Nanning, 530004, China.
  • Ren LN; College of Animal Science and Technology, Guangxi University, Nanning, 530004, China.
  • Lu YP; College of Animal Science and Technology, Guangxi University, Nanning, 530004, China.
  • Tang JW; College of Animal Science and Technology, Guangxi University, Nanning, 530004, China.
  • Lv D; College of Animal Science and Technology, Guangxi University, Nanning, 530004, China.
  • Yong L; College of Animal Science and Technology, Guangxi University, Nanning, 530004, China.
  • Lin LT; College of Animal Science and Technology, Guangxi University, Nanning, 530004, China.
  • Lin ZX; College of Animal Science and Technology, Guangxi University, Nanning, 530004, China.
  • Mo Q; Guangzhou Nasheng Biological Co., Ltd, Guangdong, 510650, China.
  • Mo ML; College of Animal Science and Technology, Guangxi University, Nanning, 530004, China. momeilan@gxu.edu.cn.
BMC Vet Res ; 18(1): 90, 2022 Mar 07.
Article in English | MEDLINE | ID: covidwho-1789121
ABSTRACT

BACKGROUND:

Infectious bronchitis virus (IBV) leads to huge economic losses in the poultry industry worldwide. The high levels of mutations of IBV render vaccines partially protective. Therefore, it is urgent to explore an effective antiviral drug or agent. The present study aimed to investigate the in vivo anti-IBV activity of a mixture of plant essential oils (PEO) of cinnamaldehyde (CA) and glycerol monolaurate (GML), designated as Jin-Jing-Zi.

RESULTS:

The antiviral effects were evaluated by clinical signs, viral loads, immune organ indices, antibody levels, and cytokine levels. The infection rates in the PEO-M (middle dose) and PEO-H (high dose) groups were significantly lower than those in the prevention, positive drug, and PEO-L (low dose) groups. The cure rates in the PEO-M and PEO-H groups were significantly higher than those in the prevention, positive drug, and PEO-L groups, and the PEO-M group had the highest cure rate of 92.31%. The symptom scores and IBV mRNA expression levels were significantly reduced in the PEO-M group. PEO significantly improved the immune organ indices and IBV-specific antibody titers of infected chickens. The anti-inflammatory factor levels of IL-4 and IFN-γ in the PEO-M group maintained high concentrations for a long time. The IL-6 levels in the PEO-M group were lower than those in prevention, positive drug, and PEO-L groups.

CONCLUSION:

The PEO had remarkable inhibition against IBV and the PEO acts by inhibiting virus multiplication and promoting immune function, suggesting that the PEO has great potential as a novel anti-IBV agent for inhibiting IBV infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Poultry Diseases / Oils, Volatile / Viral Vaccines / Coronavirus Infections / Infectious bronchitis virus Type of study: Randomized controlled trials Topics: Long Covid / Vaccines Limits: Animals Language: English Journal: BMC Vet Res Journal subject: Veterinary Medicine Year: 2022 Document Type: Article Affiliation country: S12917-022-03183-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Poultry Diseases / Oils, Volatile / Viral Vaccines / Coronavirus Infections / Infectious bronchitis virus Type of study: Randomized controlled trials Topics: Long Covid / Vaccines Limits: Animals Language: English Journal: BMC Vet Res Journal subject: Veterinary Medicine Year: 2022 Document Type: Article Affiliation country: S12917-022-03183-x