Organ function biomarker abnormalities, associated factors and disease outcome among hospitalized patients with COVID-19.
Biomark Med
; 16(6): 417-426, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1789312
ABSTRACT
Background:
The aim of this study was to determine the magnitude of abnormal organ function tests and biomarkers in hospitalized patients with confirmed COVID-19 and to define the association among markers of organ failure, disease severity and its outcome in hospitalized COVID-19 patients in Ethiopia.Methods:
A prospective cohort study was conducted among COVID-19 patients admitted to Millennium COVID-19 Treatment Center from December 2020 to June 2021.Results:
The median age of the 440 study participants was 60.3 ± 1.3 years, and from these 71.3% of patients were male. Disease severity p-value 0.032; adjusted odds ratio (AOR) (95% CI) 4.4 (0.022-0.085); and the presence of any co-morbidity; p-value 0.012; AOR (95% CI) 0.80 (0.47-0.83) was significantly associated with mortality. Aspartate transaminase, alanine transaminase and alkaline phosphatase parameter values of patients overall, were elevated - mainly among critical patients (56.9 ± 57.7, 58.5 ± 63 and 114.6 ± 60, respectively).Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19 Drug Treatment
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Biomark Med
Journal subject:
Biochemistry
/
Medicine
Year:
2022
Document Type:
Article
Affiliation country:
Bmm-2021-0681
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