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Diet and Hygiene in Modulating Autoimmunity During the Pandemic Era.
Abdelhamid, Leila; Luo, Xin M.
  • Abdelhamid L; Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.
  • Luo XM; Department of Microbiology, College of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
Front Immunol ; 12: 749774, 2021.
Article in English | MEDLINE | ID: covidwho-1789370
ABSTRACT
The immune system is an efficiently toned machinery that discriminates between friends and foes for achieving both host defense and homeostasis. Deviation of immune recognition from foreign to self and/or long-lasting inflammatory responses results in the breakdown of tolerance. Meanwhile, educating the immune system and developing immunological memory are crucial for mounting defensive immune responses while protecting against autoimmunity. Still to elucidate is how diverse environmental factors could shape autoimmunity. The emergence of a world pandemic such as SARS-CoV-2 (COVID-19) not only threatens the more vulnerable individuals including those with autoimmune conditions but also promotes an unprecedented shift in people's dietary approaches while urging for extraordinary hygiene measures that likely contribute to the development or exacerbation of autoimmunity. Thus, there is an urgent need to understand how environmental factors modulate systemic autoimmunity to better mitigate the incidence and or severity of COVID-19 among the more vulnerable populations. Here, we discuss the effects of diet (macronutrients and micronutrients) and hygiene (the use of disinfectants) on autoimmunity with a focus on systemic lupus erythematosus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Autoimmunity / Hygiene / Diet / Pandemics / SARS-CoV-2 / COVID-19 / Immune Tolerance Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.749774

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoimmune Diseases / Autoimmunity / Hygiene / Diet / Pandemics / SARS-CoV-2 / COVID-19 / Immune Tolerance Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.749774