Thrombodynamics parameters in individuals vaccinated against SARS-CoV-2

ABSTRACT

During the ongoing COVID-19 pandemic, with a significant variety of available vaccines, it is crucial to consider their effects on the hemostasis system. Objective. To study thrombodynamics features of individuals vaccinated against SARS-CoV-2 with Gam-COVID-Vac and Covi-Vac vaccines in a prospective observational study. Materials and methods. Data from 99 vaccinated individuals who completed the first three visits were analyzed. Of these, 18 were vaccinated with Gam-COVID-Vac, and 81 with CoviVac. Venous blood was collected before injection of the components I and II of the vaccine and 42 days after administration of the component I to analyze thrombodynamics parameters using the Thrombo-dynamics Analyzer System T2 (Hemacore, Russia). Results. In the analysis of thrombodynamics test data, no significant differences were found between the Gam-COVID-Vac group and the CoviVac group at any of the three stages of the study. Moreover, no significant increase in any of the parameters from the visit 1 to visit 3 was observed in both groups. Conclusion. The obtained study data suggest that such plasma hemostasis parameters as stationary rate of clot growth and ini-tial rate of clot growth, lag-time, clot density and clot size, spontaneous clots formation time show no significant changes during 42 days after the component I of Gam-COVID-Vac and CoviVac vaccines injection. © 2021, Media Sphera Publishing Group. All rights reserved.