Research Progress of Monoclonal Antibody Technology and Analysis of Marketed Drugs

ABSTRACT

Since the establishment of hybridoma in the 1980s, the antibody technology has achieved great development.Antibody is an immunoglobulin secreted by B lymphocytes, which produces many biological activity, such as blocking, neutralization, activation, kill target cells and regulate immune system via Fc receptor.The development of antibody technology has undergone a long history of mouse monoclonal antibodies, chimeric antibodies, humanized antibodies, and full human monoclonal antibodies.In the transition from mouse antibody to human antibody, a variety of biotechnology breakthroughs have been achieved, such as antibody library technology, humanized mouse technology and B cell cloning technology.Today, antibody drugs have a pivotal position throughout the drug market.Ten years come (2 011.01~2 021.11), 78 monoclonal antibody drugs have been approved for marketing by FDA, are widely distributed in the field of tumor disrases, immune diseases, anti-pathogen infections, nerves, etc.This article reviews monoclonal antibody technologies and antibody drug listing, and provides ideas for the preparation of new antibodies and the choice of drug target.