Investigation on chemical composition, antioxidant activity and SARS-CoV-2 nucleocapsid protein of endemic Ferula longipedunculata pesmen
Grasas y Aceites
; 73(1), 2022.
Article
in English
| CAB Abstracts | ID: covidwho-1792318
ABSTRACT
The essential and fatty oils were investigated and a quantitative analysis of the root, green and stem parts of F. Longipedunculata was performed by GC-MS and HPLC-TOF/MS and their antioxidant (DPPH method) activities and potential binding of phytochemicals against SARS-CoV-2 nucleocapsid were determined using Molegro Virtual Docker software. In the root part of the plant, the prominent components of oil were beta-phellandrene (53.46%), ocimene (6.79%), 4-terpineol (5.94%) and santalol (5.03%). According to the quantitative results, vanillic acid (141.35 mg/kg), ferulic acid (126.19 mg/kg) and 4-hydroxybenzoic acid (119.92 mg/kg) were found in the roots;quercetin-3-beta-O-glycoside (1737.70 mg/kg), quercetin (531.35 mg/kg) and ferulic acid (246.22 mg/kg) were found in the in the green part;and fumaric acid (2100.21 mg/kg), quercetin-3-beta-O-glycoside (163.24 mg/kg), vanillic acid (57.59 mg/kg) were detected in the stem part. The antioxidant activity of all parts of the plant was higher than the control with BHT. Silibinin, rutin, and neohesperidin exhibited a stronger affinity than nucleotides. In the silico analysis, many of the phytochemicals were attached with strong hydrogen-bonds and electrostatic effects to the amino acids to which nucleotides are bound. The results indicated that the plant showed antioxidant effects and can be effective against SARS-CoV-2 thanks to the different phytochemical compounds it contains.
Horticultural Crops [FF003]; Non-food/Non-feed Plant Products [SS200]; Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Pesticides and Drugs; Control [HH405]; chemical composition; antioxidant properties; plant composition; ferulic acid; plant extracts; antiviral properties; electrical properties; flavones; flavonols; nucleocapsid proteins; phytochemicals; quantitative techniques; quercetin; rutoside; roots; stems; Ferula; Apiaceae; Apiales; eudicots; angiosperms; Spermatophyta; plants; eukaryotes; Ferula longipedunculata; anti-oxidant properties; radical scavenging properties; chemical constituents of plants; anti-viral properties; rutin
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Language:
English
Journal:
Grasas y Aceites
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS