Cannabis Use Is Associated With Lower COVID-19 Susceptibility but Poorer Survival.
Front Public Health
; 10: 829715, 2022.
Article
in English
| MEDLINE | ID: covidwho-1792879
ABSTRACT
Objectives:
To investigate the impact of cannabis use on the infection and survival outcomes of COVID-19. StudyDesign:
Cross-sectional study based on the UK Biobank (UKB) dataset.Methods:
We identified 13,099 individuals with cannabis smoking history in the UKB COVID-19 Serology Study. The Charlson-Quan Comorbidity Index was estimated using inpatient ICD-10 records. Multivariable logistic regression characterized features associated with COVID-19 infection. Cox models determined the hazard ratios (HR) for COVID-19-related survival.Results:
Cannabis users were more likely to getting COVID-19 (odds ratio 1.22, P = 0.001) but multivariable analysis showed that cannabis use was a protective factor of COVID-19 infection (adjusted odds ratio 0.81, P = 0.001). Regular cannabis users, who smoked more than once per month, had a significantly poorer COVID-19-related survival, after adjusting for known risk factors including age, gender, smoking history, and comorbidity (adjusted hazard ratio 2.81, P = 0.041).Conclusions:
The frequency of cannabis use could be considered as a candidate predictor for mortality risk of COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cannabis
/
Marijuana Smoking
/
COVID-19
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
Front Public Health
Year:
2022
Document Type:
Article
Affiliation country:
Fpubh.2022.829715
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