Fast Ion-Beam Inactivation of Viruses, Where Radiation Track Structure Meets RNA Structural Biology.
Radiat Res
; 198(1): 68-80, 2022 07 01.
Article
in English
| MEDLINE | ID: covidwho-1793416
ABSTRACT
Here we show an interplay between the structures present in ionization tracks and nucleocapsid RNA structural biology, using fast ion-beam inactivation of the severe acute respiratory syndrome coronavirus (SARS-CoV) virion as an example. This interplay could be a key factor in predicting dose-inactivation curves for high-energy ion-beam inactivation of virions. We also investigate the adaptation of well-established cross-section data derived from radiation interactions with water to the interactions involving the components of a virion, going beyond the density-scaling approximation developed previously. We conclude that solving one of the grand challenges of structural biology - the determination of RNA tertiary/quaternary structure - is linked to predicting ion-beam inactivation of viruses and that the two problems can be mutually informative. Indeed, our simulations show that fast ion beams have a key role to play in elucidating RNA tertiary/quaternary structure.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA, Viral
/
Virus Inactivation
/
SARS-CoV-2
/
Nucleic Acid Conformation
Type of study:
Prognostic study
/
Randomized controlled trials
Language:
English
Journal:
Radiat Res
Year:
2022
Document Type:
Article
Affiliation country:
Rade-21-00133.1
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