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Biological evaluation of a mechanical ventilator that operates by controlling an automated manual resuscitator. A descriptive study in swine.
Gonzales Carazas, Maryanne Melanie; Gavidia, Cesar Miguel; Davila Fernandez, Roberto; Vargas Zuñiga, Juan Alberto; Crespo Paiva, Alberto; Bocanegra, William; Calderon, Joan; Sanchez, Evelyn; Perales, Rosa; Zeña, Brandon; Calcina Isique, Juan Fernando; Reategui, Jaime; Castañeda, Benjamin; Casado, Fanny L.
  • Gonzales Carazas MM; Institute of Omics and Applied Biotechnology, Pontificia Universidad Catolica del Peru, Lima, Peru.
  • Gavidia CM; School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
  • Davila Fernandez R; School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
  • Vargas Zuñiga JA; Centro de Urgencias Veterinarias (CUVET), Lima, Peru.
  • Crespo Paiva A; Instituto Veterinario de Oftalmologia (IVO), Lima, Peru.
  • Bocanegra W; School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
  • Calderon J; School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
  • Sanchez E; School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
  • Perales R; School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
  • Zeña B; Instituto Veterinario de Oftalmologia (IVO), Lima, Peru.
  • Calcina Isique JF; School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
  • Reategui J; Brein, Lima, Peru.
  • Castañeda B; Institute of Omics and Applied Biotechnology, Pontificia Universidad Catolica del Peru, Lima, Peru.
  • Casado FL; Department of Engineering, Pontificia Universidad Catolica del Peru, Lima, Peru.
PLoS One ; 17(3): e0264774, 2022.
Article in English | MEDLINE | ID: covidwho-1793507
ABSTRACT
The Covid-19 outbreak challenged health systems around the world to design and implement cost-effective devices produced locally to meet the increased demand of mechanical ventilators worldwide. This study evaluates the physiological responses of healthy swine maintained under volume- or pressure-controlled mechanical ventilation by a mechanical ventilator implemented to bring life-support by automating a resuscitation bag and closely controlling ventilatory parameters. Physiological parameters were monitored in eight sedated animals (t0) prior to inducing deep anaesthesia, and during the next six hours of mechanical ventilation (t1-7). Hemodynamic conditions were monitored periodically using a portable gas analyser machine (i.e. BEecf, carbonate, SaO2, lactate, pH, PaO2, PaCO2) and a capnometer (i.e. ETCO2). Electrocardiogram, echocardiography and lung ultrasonography were performed to detect in vivo alterations in these vital organs and pathological findings from necropsy were reported. The mechanical ventilator properly controlled physiological levels of blood biochemistry such as oxygenation parameters (PaO2, PaCO2, SaO2, ETCO2), acid-base equilibrium (pH, carbonate, BEecf), and perfusion of tissues (lactate levels). In addition, histopathological analysis showed no evidence of acute tissue damage in lung, heart, liver, kidney, or brain. All animals were able to breathe spontaneously after undergoing mechanical ventilation. These preclinical data, supports the biological safety of the medical device to move forward to further evaluation in clinical studies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / Ventilators, Mechanical / Cardiopulmonary Resuscitation Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Animals Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0264774

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / Ventilators, Mechanical / Cardiopulmonary Resuscitation Type of study: Experimental Studies / Prognostic study Topics: Long Covid Limits: Animals Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0264774