Severe COVID-19-associated variants linked to chemokine receptor gene control in monocytes and macrophages.
Genome Biol
; 23(1): 96, 2022 04 14.
Article
in English
| MEDLINE | ID: covidwho-1793837
ABSTRACT
Genome-wide association studies have identified 3p21.31 as the main risk locus for severe COVID-19, although underlying mechanisms remain elusive. We perform an epigenomic dissection of 3p21.31, identifying a CTCF-dependent tissue-specific 3D regulatory chromatin hub that controls the activity of several chemokine receptor genes. Risk SNPs colocalize with regulatory elements and are linked to increased expression of CCR1, CCR2 and CCR5 in monocytes and macrophages. As excessive organ infiltration of inflammatory monocytes and macrophages is a hallmark of severe COVID-19, our findings provide a rationale for the genetic association of 3p21.31 variants with elevated risk of hospitalization upon SARS-CoV-2 infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Monocytes
/
COVID-19
Type of study:
Prognostic study
Topics:
Variants
Limits:
Humans
Language:
English
Journal:
Genome Biol
Journal subject:
Molecular Biology
/
Genetics
Year:
2022
Document Type:
Article
Affiliation country:
S13059-022-02669-Z
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