Adherence to Antiretroviral Therapy and Associated Factors Among People Living With HIV Following the Introduction of Dolutegravir Based Regimens in Dar es Salaam, Tanzania.
J Int Assoc Provid AIDS Care
; 21: 23259582221084543, 2022.
Article
in English
| MEDLINE | ID: covidwho-1794048
ABSTRACT
Background:
Adherence to antiretroviral therapy (ART) is the key determinant of virological suppression in people living with HIV (PLHIV). This study reports factors associated with non-adherence among PLHIV one year after introducing dolutegravir (DTG) based regimens in Tanzania.Methods:
A hospital-based cross-sectional study was conducted in two health facilities in Dar es Salaam, Tanzania, in 2020.Results:
A total of 406 PLHIV were recruited, where the majority (73.4%) were females, with 94.6% of patients being on DTG based regimens. Factors such as refill interval and sharing of antiretrovirals had significant effects on adherence. Multivariate analysis found that patients attending care and treatment center (CTC) at Temeke Regional Referral Hospital (RRH) were 4.3 times more likely to have non-adherence compared to those attending Amana RRH (aOR [adjusted odds ratio] 4.3, 95% CI [confidence interval] 2.38 - 7.91, p-value < 0.0001).Conclusions:
Sustainable adherence counseling is warranted to overcome non-adherence to ART.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
HIV Infections
Type of study:
Observational study
/
Prognostic study
/
Qualitative research
/
Randomized controlled trials
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Africa
Language:
English
Journal:
J Int Assoc Provid AIDS Care
Year:
2022
Document Type:
Article
Affiliation country:
23259582221084543
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