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Adherence to Antiretroviral Therapy and Associated Factors Among People Living With HIV Following the Introduction of Dolutegravir Based Regimens in Dar es Salaam, Tanzania.
Kilapilo, Mary Spicar; Sangeda, Raphael Zozimus; Bwire, George M; Sambayi, Godfrey Leonard; Mosha, Idda Hubert; Killewo, Japhet.
  • Kilapilo MS; Department of Pharmaceutical Microbiology, 92976Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
  • Sangeda RZ; Department of Pharmaceutical Microbiology, 92976Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
  • Bwire GM; Department of Pharmaceutical Microbiology, 92976Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
  • Sambayi GL; Department of Pharmacognosy,92976 Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
  • Mosha IH; Department of Behavioural Sciences, 92976Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
  • Killewo J; Department of Biostatistics and Epidemiology, 92976Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
J Int Assoc Provid AIDS Care ; 21: 23259582221084543, 2022.
Article in English | MEDLINE | ID: covidwho-1794048
ABSTRACT

Background:

Adherence to antiretroviral therapy (ART) is the key determinant of virological suppression in people living with HIV (PLHIV). This study reports factors associated with non-adherence among PLHIV one year after introducing dolutegravir (DTG) based regimens in Tanzania.

Methods:

A hospital-based cross-sectional study was conducted in two health facilities in Dar es Salaam, Tanzania, in 2020.

Results:

A total of 406 PLHIV were recruited, where the majority (73.4%) were females, with 94.6% of patients being on DTG based regimens. Factors such as refill interval and sharing of antiretrovirals had significant effects on adherence. Multivariate analysis found that patients attending care and treatment center (CTC) at Temeke Regional Referral Hospital (RRH) were 4.3 times more likely to have non-adherence compared to those attending Amana RRH (aOR [adjusted odds ratio] 4.3, 95% CI [confidence interval] 2.38 - 7.91, p-value < 0.0001).

Conclusions:

Sustainable adherence counseling is warranted to overcome non-adherence to ART.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections Type of study: Observational study / Prognostic study / Qualitative research / Randomized controlled trials Limits: Female / Humans / Male Country/Region as subject: Africa Language: English Journal: J Int Assoc Provid AIDS Care Year: 2022 Document Type: Article Affiliation country: 23259582221084543

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HIV Infections Type of study: Observational study / Prognostic study / Qualitative research / Randomized controlled trials Limits: Female / Humans / Male Country/Region as subject: Africa Language: English Journal: J Int Assoc Provid AIDS Care Year: 2022 Document Type: Article Affiliation country: 23259582221084543