Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.
Circ Res
; 130(10): 1510-1530, 2022 05 13.
Article
in English
| MEDLINE | ID: covidwho-1794328
ABSTRACT
BACKGROUND:
Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of atherosclerotic plaques containing immune cells in various states of activation and differentiation. Understanding how these immune cells contribute to disease progression may lead to the development of novel therapeutic strategies.METHODS:
We used single-cell technology and in vitro assays to interrogate the immune microenvironment of human coronary atherosclerotic plaque at different stages of maturity.RESULTS:
In addition to macrophages, we found a high proportion of αß T cells in the coronary plaques. Most of these T cells lack high expression of CCR7 and L-selectin, indicating that they are primarily antigen-experienced memory cells. Notably, nearly one-third of these cells express the HLA-DRA surface marker, signifying activation through their TCRs (T-cell receptors). Consistent with this, TCR repertoire analysis confirmed the presence of activated αß T cells (CD4CONCLUSIONS:
Taken together, these findings demonstrate that plaque T cells are clonally expanded potentially by antigen engagement, are potentially reactive to self-epitopes, and may interact with smooth muscle cells and macrophages in the plaque microenvironment.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coronary Artery Disease
/
T-Lymphocytes
/
Plaque, Atherosclerotic
Type of study:
Randomized controlled trials
Limits:
Humans
Language:
English
Journal:
Circ Res
Year:
2022
Document Type:
Article
Affiliation country:
Circresaha.121.320090
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