Disparities in time to start of definitive radiation treatment for patients with locally advanced cervical cancer.
Int J Gynecol Cancer
; 32(5): 613-618, 2022 05 03.
Article
in English
| MEDLINE | ID: covidwho-1794469
ABSTRACT
BACKGROUND:
Chemoradiation or radiation therapy alone are curative standards for patients with locally advanced cervical cancer.OBJECTIVE:
To investigate factors that influence time to initiation of chemoradiation or radiation and the subsequent impact of time to treatment on recurrence and survival outcomes.METHODS:
Patients with locally advanced cervical cancer treated with definitive chemoradiation or radiation at our institution between November 2015 and August 2020 were retrospectively identified. Time to treatment initiation was defined as the number of days from date of diagnosis (via biopsy) to the start date of radiation. The cohort was stratified by the median time to treatment into early (<75 days) and delayed (≥75 days) cohorts. Multivariable logistic regression was conducted to examine factors associated with delayed time to treatment.RESULTS:
We identified 143 patients with locally advanced cervical cancer who underwent definitive chemoradiation or radiation. Median follow-up time was 18 months (range 2-62). A total of 71 (49.7%) patients had time to treatment <75 days and 72 (50.3%) patients had time to treatment ≥75 days. The delayed cohort had a higher proportion of Hispanic patients (51.4% vs 31.0%, p=0.04). In multivariable modeling, Hispanic women were 2.71 times more likely (p=0.04) to undergo delayed time to treatment than non-Hispanic white women. Additionally, patients with stage >IIB disease were less likely to undergo delayed time to treatment (OR 0.26, p=0.02) than patients with stageCONCLUSION:
Hispanic patients with locally advanced cervical cancer were more likely to receive delayed time to definitive treatment of ≥75 days. Further studies examining the presence of similar disparities in delay to definitive treatment for locally advanced cervical cancer at other institutions and settings are warranted.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Uterine Cervical Neoplasms
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Int J Gynecol Cancer
Journal subject:
Gynecology
/
Neoplasms
Year:
2022
Document Type:
Article
Affiliation country:
Ijgc-2021-003305
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