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Early Experiences With COVID-19 Testing in Transplantation.
Boyarsky, Brian J; Massie, Allan B; Love, Arthur D; Werbel, William A; Durand, Christine M; Avery, Robin K; Jackson, Kyle R; Kernodle, Amber B; Thomas, Alvin G; Ronin, Matthew; Altrich, Michelle; Niles, Patricia; Trahan, Chad; Hewlett, Jonathan; Segev, Dorry L; Garonzik-Wang, Jacqueline M.
  • Boyarsky BJ; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Massie AB; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Love AD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.
  • Werbel WA; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Durand CM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Avery RK; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Jackson KR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Kernodle AB; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Thomas AG; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Ronin M; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Altrich M; National Kidney Registry, Babylon, NY.
  • Niles P; Viracor Eurofins, Lee's Summit, MO.
  • Trahan C; Southwest Transplant Alliance, Dallas, TX.
  • Hewlett J; Southwest Transplant Alliance, Dallas, TX.
  • Segev DL; Southwest Transplant Alliance, Dallas, TX.
  • Garonzik-Wang JM; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Transplant Direct ; 6(7): e572, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-1794966
Semantic information from SemMedBD (by NLM)
1. COVID-19 OCCURS_IN Donor person
Subject
COVID-19
Predicate
OCCURS_IN
Object
Donor person
2. COVID-19 OCCURS_IN Health Personnel
Subject
COVID-19
Predicate
OCCURS_IN
Object
Health Personnel
3. COVID-19 OCCURS_IN Transplant Recipients
Subject
COVID-19
Predicate
OCCURS_IN
Object
Transplant Recipients
4. Cessation of life PROCESS_OF Donor person
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Donor person
5. Kidney Failur PROCESS_OF C0030705
Subject
Kidney Failur
Predicate
PROCESS_OF
Object
C0030705
6. COVID-19 PROCESS_OF Donor person
Subject
COVID-19
Predicate
PROCESS_OF
Object
Donor person
7. COVID-19 PROCESS_OF Health Personnel
Subject
COVID-19
Predicate
PROCESS_OF
Object
Health Personnel
8. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
9. COVID-19 OCCURS_IN Donor person
Subject
COVID-19
Predicate
OCCURS_IN
Object
Donor person
10. COVID-19 OCCURS_IN Health Personnel
Subject
COVID-19
Predicate
OCCURS_IN
Object
Health Personnel
11. COVID-19 OCCURS_IN Transplant Recipients
Subject
COVID-19
Predicate
OCCURS_IN
Object
Transplant Recipients
12. Cessation of life PROCESS_OF Donor person
Subject
Cessation of life
Predicate
PROCESS_OF
Object
Donor person
13. Kidney Failure, Chronic PROCESS_OF Patients
Subject
Kidney Failure, Chronic
Predicate
PROCESS_OF
Object
Patients
14. COVID-19 PROCESS_OF Donor person
Subject
COVID-19
Predicate
PROCESS_OF
Object
Donor person
15. COVID-19 PROCESS_OF Health Personnel
Subject
COVID-19
Predicate
PROCESS_OF
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Health Personnel
16. COVID-19 PROCESS_OF Patients
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COVID-19
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PROCESS_OF
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Patients
ABSTRACT

BACKGROUND:

The early effects of coronavirus disease 2019 (COVID-19) on transplantation are dramatic >75% of kidney and liver programs are either suspended or operating under major restrictions. To resume transplantation, it is important to understand the prevalence of COVID-19 among transplant recipients, donors, and healthcare workers (HCWs) and its associated mortality.

METHODS:

To investigate this, we studied severe acute respiratory syndrome coronavirus 2 diagnostic test results among patients with end-stage renal disease or kidney transplants from the Johns Hopkins Health System (n = 235), and screening test results from deceased donors from the Southwest Transplant Alliance Organ Procurement Organization (n = 27), and donors, candidates, and HCWs from the National Kidney Registry and Viracor-Eurofins (n = 253) between February 23 and April 15, 2020.

RESULTS:

We found low rates of COVID-19 among donors and HCWs (0%-1%) who were screened, higher rates of diagnostic tests among patients with end-stage renal disease or kidney transplant (17%-20%), and considerable mortality (7%-13%) among those who tested positive.

CONCLUSIONS:

These findings suggest the threat of COVID-19 for the transplant population is significant and ongoing data collection and reporting is critical to inform transplant practices during and after the pandemic.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Observational study / Qualitative research Language: English Journal: Transplant Direct Year: 2020 Document Type: Article Affiliation country: TXD.0000000000001024

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Observational study / Qualitative research Language: English Journal: Transplant Direct Year: 2020 Document Type: Article Affiliation country: TXD.0000000000001024