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Severe Acute Respiratory Syndrome Coronavirus 2 Anti-Spike Antibody Levels Following Second Dose of ChAdOx1 nCov-19 or BNT162b2 Vaccine in Residents of Long-term Care Facilities in England (VIVALDI).
Stirrup, Oliver; Krutikov, Maria; Tut, Gokhan; Palmer, Tom; Bone, David; Bruton, Rachel; Fuller, Chris; Azmi, Borscha; Lancaster, Tara; Sylla, Panagiota; Kaur, Nayandeep; Spalkova, Eliska; Bentley, Christopher; Amin, Umayr; Jadir, Azar; Hulme, Samuel; Giddings, Rebecca; Nacer-Laidi, Hadjer; Baynton, Verity; Irwin-Singer, Aidan; Hayward, Andrew; Moss, Paul; Copas, Andrew; Shallcross, Laura.
  • Stirrup O; Institute for Global Health, University College London, United Kingdom.
  • Krutikov M; Institute of Health Informatics, University College London, United Kingdom.
  • Tut G; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Palmer T; Institute for Global Health, University College London, United Kingdom.
  • Bone D; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Bruton R; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Fuller C; Institute of Health Informatics, University College London, United Kingdom.
  • Azmi B; Institute of Health Informatics, University College London, United Kingdom.
  • Lancaster T; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Sylla P; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Kaur N; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Spalkova E; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Bentley C; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Amin U; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Jadir A; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Hulme S; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Giddings R; Institute of Health Informatics, University College London, United Kingdom.
  • Nacer-Laidi H; Institute of Health Informatics, University College London, United Kingdom.
  • Baynton V; Department of Health and Social Care, London, United Kingdom.
  • Irwin-Singer A; Department of Health and Social Care, London, United Kingdom.
  • Hayward A; Institute of Epidemiology and Health Care, University College London, United Kingdom.
  • Moss P; Health Data Research UK, London, United Kingdom.
  • Copas A; Institute of Immunology and Immunotherapy, University of Birmingham, United Kingdom.
  • Shallcross L; Institute for Global Health, University College London, United Kingdom.
J Infect Dis ; 226(11): 1877-1881, 2022 Nov 28.
Article in English | MEDLINE | ID: covidwho-1883018
ABSTRACT
General population studies have shown strong humoral response following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination with subsequent waning of anti-spike antibody levels. Vaccine-induced immune responses are often attenuated in frail and older populations, but published data are scarce. We measured SARS-CoV-2 anti-spike antibody levels in long-term care facility residents and staff following a second vaccination dose with Oxford-AstraZeneca or Pfizer-BioNTech. Vaccination elicited robust antibody responses in older residents, suggesting comparable levels of vaccine-induced immunity to that in the general population. Antibody levels are higher after Pfizer-BioNTech vaccination but fall more rapidly compared to Oxford-AstraZeneca recipients and are enhanced by prior infection in both groups.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Aged / Humans Country/Region as subject: Europa Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Experimental Studies / Randomized controlled trials Topics: Vaccines Limits: Aged / Humans Country/Region as subject: Europa Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis